Laterality Alone Should Not Drive Selection of Candidates for Hemi-Ablative Focal Therapy

Basir Tareen, Guilherme Godoy, Alex Sankin, Steve Temkin, Herbert Lepor, Samir S. Taneja

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

Purpose: Because many investigators have suggested that ideal candidates for focal therapy are those with unilateral prostate cancer, we evaluated whether these men are at decreased risk for adverse pathological and oncological outcomes. Materials and Methods: We reviewed the charts of 1,458 consecutive patients who underwent open radical prostatectomy, as performed by a single surgeon. Patients were divided into 311 with unilateral (group 1) and 1,147 with bilateral (group 2) disease on final surgical pathology. They were also substratified by clinical risk into low risk (prostate specific antigen less than 10 ng/ml, clinical stage less than T2b or Gleason score less than 7) and high risk groups. The groups were compared with respect to extracapsular extension, seminal vesical invasion, percent of tumor involvement, pathological Gleason score and biochemical recurrence. Results: Compared to patients with bilateral disease those with unilateral disease had a lower rate of extracapsular extension (p = 0.004), seminal vesical invasion (p = 0.003), greater than 10% tumor involvement (p <0.001) and Gleason score 7 or greater (p <0.001). At a median followup of 36 months 8.3% and 16.7% of the men in groups 1 and 2, respectively, experienced biochemical recurrence (p = 0.001). Low risk disease was more prevalent in those with unilateral disease than in those with bilateral disease. Of men with low risk disease the risk of adverse pathological features/biochemical recurrence did not differ between groups 1 and 2. Conclusions: Although men with unilateral prostate cancer have more favorable oncological outcomes than those with bilateral prostate cancer, this appears to be due to the higher prevalence of low risk disease. While focality/laterality may direct the method of subtotal gland treatment, clinical risk features may be adequate to select candidates for focal therapy.

Original languageEnglish (US)
Pages (from-to)1082-1090
Number of pages9
JournalJournal of Urology
Volume181
Issue number3
DOIs
StatePublished - Mar 1 2009
Externally publishedYes

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Keywords

  • functional laterality
  • outcome assessment (health care)
  • prostate
  • prostatic neoplasms
  • risk

ASJC Scopus subject areas

  • Urology

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