Lateral border zone: Quantitation of lateral extension of subendocardial infarction in the dog

Robert Forman, S. Cho, S. M. Factor, E. S. Kirk

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

This study was undertaken to quantitate the lateral extension that occurs concomitantly with the transmural extension of a subendocardial infarction. A subendocardial infarct was produced in 12 dogs by a 40 minute temporary coronary artery occlusion. Infarct extension was induced 7 days later by permanent occlusion of the same vessel. Regional myocardial blood flows confirmed that ischemia had been produced with both coronary artery occlusions. The vascular boundaries between the normally perfused and ischemic beds were defined by perfusion with different-colored Microfil solutions. The extent of subendocardial infarction and subsequent transmural and lateral extensions were assessed by point counting of histologic specimens. The initial temporary occlusion produced a 30.0 ± 4.2% transmural infarct and the subsequent permanent occlusion a 29.2 ± 3.5% transmural extension in a risk region of 39 ± 4 g. Lateral extension was not measured in four dogs because the initial subendocardial infarct was patchy with markedly irregular lateral borders. In eight dogs the size of the measured lateral infarct extension from each lateral margin from two histologic sections was 0.63 ± 0.013 cm2. The area of both lateral extensions was 1.7 ± 0.1% of the cross-sectional area of its risk region as determined by planimetry. Using a model of the risk region, the mass of the lateral extension was estimated to be 1.4 ± 0.3 g or 3.5 ± 0.6% of the region at risk. Thus, at the lateral margin of a subendocardial infarct there is a border zone that is small relative to the size of the region at risk and infarcted myocardium. This border zone is not a site at which a significant volume of myocardium can be salvaged or into which significant extension can occur.

Original languageEnglish (US)
Pages (from-to)1125-1131
Number of pages7
JournalJournal of the American College of Cardiology
Volume5
Issue number5
StatePublished - 1985
Externally publishedYes

Fingerprint

Infarction
Dogs
Coronary Occlusion
Coronary Vessels
Myocardium
Silicone Elastomers
Regional Blood Flow
Blood Vessels
Ischemia
Perfusion

ASJC Scopus subject areas

  • Nursing(all)

Cite this

Lateral border zone : Quantitation of lateral extension of subendocardial infarction in the dog. / Forman, Robert; Cho, S.; Factor, S. M.; Kirk, E. S.

In: Journal of the American College of Cardiology, Vol. 5, No. 5, 1985, p. 1125-1131.

Research output: Contribution to journalArticle

@article{e34bdbe810414a0f9fccee2e979cfa33,
title = "Lateral border zone: Quantitation of lateral extension of subendocardial infarction in the dog",
abstract = "This study was undertaken to quantitate the lateral extension that occurs concomitantly with the transmural extension of a subendocardial infarction. A subendocardial infarct was produced in 12 dogs by a 40 minute temporary coronary artery occlusion. Infarct extension was induced 7 days later by permanent occlusion of the same vessel. Regional myocardial blood flows confirmed that ischemia had been produced with both coronary artery occlusions. The vascular boundaries between the normally perfused and ischemic beds were defined by perfusion with different-colored Microfil solutions. The extent of subendocardial infarction and subsequent transmural and lateral extensions were assessed by point counting of histologic specimens. The initial temporary occlusion produced a 30.0 ± 4.2{\%} transmural infarct and the subsequent permanent occlusion a 29.2 ± 3.5{\%} transmural extension in a risk region of 39 ± 4 g. Lateral extension was not measured in four dogs because the initial subendocardial infarct was patchy with markedly irregular lateral borders. In eight dogs the size of the measured lateral infarct extension from each lateral margin from two histologic sections was 0.63 ± 0.013 cm2. The area of both lateral extensions was 1.7 ± 0.1{\%} of the cross-sectional area of its risk region as determined by planimetry. Using a model of the risk region, the mass of the lateral extension was estimated to be 1.4 ± 0.3 g or 3.5 ± 0.6{\%} of the region at risk. Thus, at the lateral margin of a subendocardial infarct there is a border zone that is small relative to the size of the region at risk and infarcted myocardium. This border zone is not a site at which a significant volume of myocardium can be salvaged or into which significant extension can occur.",
author = "Robert Forman and S. Cho and Factor, {S. M.} and Kirk, {E. S.}",
year = "1985",
language = "English (US)",
volume = "5",
pages = "1125--1131",
journal = "Journal of the American College of Cardiology",
issn = "0735-1097",
publisher = "Elsevier USA",
number = "5",

}

TY - JOUR

T1 - Lateral border zone

T2 - Quantitation of lateral extension of subendocardial infarction in the dog

AU - Forman, Robert

AU - Cho, S.

AU - Factor, S. M.

AU - Kirk, E. S.

PY - 1985

Y1 - 1985

N2 - This study was undertaken to quantitate the lateral extension that occurs concomitantly with the transmural extension of a subendocardial infarction. A subendocardial infarct was produced in 12 dogs by a 40 minute temporary coronary artery occlusion. Infarct extension was induced 7 days later by permanent occlusion of the same vessel. Regional myocardial blood flows confirmed that ischemia had been produced with both coronary artery occlusions. The vascular boundaries between the normally perfused and ischemic beds were defined by perfusion with different-colored Microfil solutions. The extent of subendocardial infarction and subsequent transmural and lateral extensions were assessed by point counting of histologic specimens. The initial temporary occlusion produced a 30.0 ± 4.2% transmural infarct and the subsequent permanent occlusion a 29.2 ± 3.5% transmural extension in a risk region of 39 ± 4 g. Lateral extension was not measured in four dogs because the initial subendocardial infarct was patchy with markedly irregular lateral borders. In eight dogs the size of the measured lateral infarct extension from each lateral margin from two histologic sections was 0.63 ± 0.013 cm2. The area of both lateral extensions was 1.7 ± 0.1% of the cross-sectional area of its risk region as determined by planimetry. Using a model of the risk region, the mass of the lateral extension was estimated to be 1.4 ± 0.3 g or 3.5 ± 0.6% of the region at risk. Thus, at the lateral margin of a subendocardial infarct there is a border zone that is small relative to the size of the region at risk and infarcted myocardium. This border zone is not a site at which a significant volume of myocardium can be salvaged or into which significant extension can occur.

AB - This study was undertaken to quantitate the lateral extension that occurs concomitantly with the transmural extension of a subendocardial infarction. A subendocardial infarct was produced in 12 dogs by a 40 minute temporary coronary artery occlusion. Infarct extension was induced 7 days later by permanent occlusion of the same vessel. Regional myocardial blood flows confirmed that ischemia had been produced with both coronary artery occlusions. The vascular boundaries between the normally perfused and ischemic beds were defined by perfusion with different-colored Microfil solutions. The extent of subendocardial infarction and subsequent transmural and lateral extensions were assessed by point counting of histologic specimens. The initial temporary occlusion produced a 30.0 ± 4.2% transmural infarct and the subsequent permanent occlusion a 29.2 ± 3.5% transmural extension in a risk region of 39 ± 4 g. Lateral extension was not measured in four dogs because the initial subendocardial infarct was patchy with markedly irregular lateral borders. In eight dogs the size of the measured lateral infarct extension from each lateral margin from two histologic sections was 0.63 ± 0.013 cm2. The area of both lateral extensions was 1.7 ± 0.1% of the cross-sectional area of its risk region as determined by planimetry. Using a model of the risk region, the mass of the lateral extension was estimated to be 1.4 ± 0.3 g or 3.5 ± 0.6% of the region at risk. Thus, at the lateral margin of a subendocardial infarct there is a border zone that is small relative to the size of the region at risk and infarcted myocardium. This border zone is not a site at which a significant volume of myocardium can be salvaged or into which significant extension can occur.

UR - http://www.scopus.com/inward/record.url?scp=0021819991&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021819991&partnerID=8YFLogxK

M3 - Article

C2 - 3989124

AN - SCOPUS:0021819991

VL - 5

SP - 1125

EP - 1131

JO - Journal of the American College of Cardiology

JF - Journal of the American College of Cardiology

SN - 0735-1097

IS - 5

ER -