Latent tuberculosis: Models, mechanisms, and novel prospects for eradication

Paul F. Riska, Stephen Carleton

Research output: Contribution to journalReview article

9 Scopus citations

Abstract

Latent tuberculosis (TB) infects one-third of the world. We present evidence for the existence of a latent state of TB in humans, cite new approaches to diagnosis and treatment, and identify several models that attempt to mimic the latent state. Persistent infection in mice and in vitro systems of microaerophilic and/or anaerobic growth and nutrient starvation have been the most productive models in yielding insights into the host and mycobacterial pathways involved in the latent state. These pathways may serve as targets for better diagnosis, treatment, and prevention of latent TB in man.

Original languageEnglish (US)
Pages (from-to)263-272
Number of pages10
JournalSeminars in Pediatric Infectious Diseases
Volume13
Issue number4
DOIs
StatePublished - Oct 2002

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Microbiology (medical)

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