Late cardiovascular and pulmonary complications of therapy in hodgkin's disease: Report of three unusual cases, with a review of relevant literature

Chaim Putterman, Aaron Polliack

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

With the advent of modern therapeutic approaches, even patients with advanced Hodgkin's disease have high cure rates today. Therefore, more attention is gradually being focused upon the late complications of chemotherapy and irradiation, appearing long after the patient is in remission and thought to be cured. In this report, we review the incidence and presentation of some of the cardiovascular and pulmonary complications which may appear later in the course of the disease. Cardiovascular mishaps reviewed include pericardial manifestations, conduction abnormalities, cardiomyopathy, and premature coronary artery disease. Pulmonary complications discussed are lung fibrosis, spontaneous pneumothorax, pulmonary veno-occlusive disease, and hyperlucent lung. Three instructive cases from our recent experience, are also presented. One fatal case was due to cardiac failure because of radiation-induced pericarditis and coronary artery disease. Another patient with an almost fatal complication required lung transplantation because of severe bilateral radiation fibrosis of the lung and pulmonary veno-occlusive disease. The third instance was also life-threatening in nature, with radiation-induced arterial changes in the major arteries of the chest and neck, resulting in recurrent cerebral and ophthalmic thrombo-embolic disease. It is suggested that potentially severe cardiopulmonary complications be considered during the planning of the initial and subsequent management of patients with Hodgkin's disease, particularly in an era employing autologous and allogeneic bone marrow transplantation as part of therapy in some cases.

Original languageEnglish (US)
Pages (from-to)109-115
Number of pages7
JournalLeukemia and Lymphoma
Volume7
Issue number1-2
DOIs
StatePublished - 1992
Externally publishedYes

Fingerprint

Hodgkin Disease
Pulmonary Veno-Occlusive Disease
Lung
Coronary Artery Disease
Hyperlucent Lung
Radiation
Radiation Pneumonitis
Pericarditis
Lung Transplantation
Homologous Transplantation
Pneumothorax
Therapeutics
Bone Marrow Transplantation
Cardiomyopathies
Fibrosis
Neck
Thorax
Heart Failure
Arteries
Drug Therapy

Keywords

  • Cardiovascular
  • Chemotherapy
  • Hodgkin's disease
  • Late complications
  • Pulmonary
  • Radiotherapy

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Cite this

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