Laryngeal keratinocytes show variable inhibition of replication by TGF-β

Teresa P. DiLorenzo, Bettie M. Steinberg

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The response of secondary human laryngeal epithelial cells to transforming growth factor-β (TGF-β) was investigated, and this response was compared with that of epithelial cells derived from virally induced laryngeal papillomas. In most cases, both normal laryngeal epithelial cells and those derived from laryngeal papillomas exhibited growth inhibition in response to 10ngml-1 TGF-β. Response was not a function of cell density or proliferation rate when cells were in a low-calcium medium, but was reduced in high calcium. Using keratinocytes derived from several different tissue explants, we found that cells grown from different explants show marked variation in response to TGF-β.

Original languageEnglish (US)
Pages (from-to)115-119
Number of pages5
JournalJournal of Cell Science
Volume96
Issue number1
StatePublished - May 1990

Fingerprint

Transforming Growth Factors
Keratinocytes
Epithelial Cells
Papilloma
Calcium
Cell Count
Cell Proliferation
Growth

Keywords

  • Keratinocytes
  • Laryngeal
  • Papilloma
  • TGF-β

ASJC Scopus subject areas

  • Cell Biology

Cite this

Laryngeal keratinocytes show variable inhibition of replication by TGF-β. / DiLorenzo, Teresa P.; Steinberg, Bettie M.

In: Journal of Cell Science, Vol. 96, No. 1, 05.1990, p. 115-119.

Research output: Contribution to journalArticle

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