Large fetal sacrococcygeal teratomas: Could early delivery improve outcome?

Cynthia J. Holcroft; Karin J. Blakemore; Edith D. Gurewitsch; Rita W. Driggers; Frances J. Northington; Anne C. Fischer

doi:10.1159/000132408

Large fetal sacrococcygeal teratomas: Could early delivery improve outcome?

Cynthia J. Holcroft, Karin J. Blakemore, Edith D. Gurewitsch, Rita W. Driggers, Frances J. Northington, Anne C. Fischer

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Objective: To determine if gestational age (GA) at delivery or tumor size impacts outcome in neonates with very large sacrococcygeal teratomas (SCTs). Methods: Retrospective chart review from 1990 to 2006 of live-born infants with very large SCTs, defined as diameters exceeding 10 cm. Data analyzed using the independent t test and Fisher's exact test, with p values <0.05 considered significant. Results: Nine infants with very large SCTs were identified. Six of the 9 infants survived, 4 of whom had evidence of early hydrops. Mean GA of survivors was 32.2 ± 3.7 versus 31.7 ± 0.6 weeks in nonsurvivors (p = 0.85). Infants with the largest SCTs did not survive. Conclusion: Risks of preterm delivery must be weighed against complications from further enlargement of very large SCTs and against the risks of in utero intervention.

Original language	English (US)
Pages (from-to)	55-60
Number of pages	6
Journal	Fetal Diagnosis and Therapy
Volume	24
Issue number	1
DOIs	https://doi.org/10.1159/000132408
State	Published - Jul 2008
Externally published	Yes

Keywords

Prematurity
Sacrococcygeal teratoma
Survival

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Embryology
Radiology Nuclear Medicine and imaging
Obstetrics and Gynecology

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10.1159/000132408

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title = "Large fetal sacrococcygeal teratomas: Could early delivery improve outcome?",

abstract = "Objective: To determine if gestational age (GA) at delivery or tumor size impacts outcome in neonates with very large sacrococcygeal teratomas (SCTs). Methods: Retrospective chart review from 1990 to 2006 of live-born infants with very large SCTs, defined as diameters exceeding 10 cm. Data analyzed using the independent t test and Fisher's exact test, with p values <0.05 considered significant. Results: Nine infants with very large SCTs were identified. Six of the 9 infants survived, 4 of whom had evidence of early hydrops. Mean GA of survivors was 32.2 ± 3.7 versus 31.7 ± 0.6 weeks in nonsurvivors (p = 0.85). Infants with the largest SCTs did not survive. Conclusion: Risks of preterm delivery must be weighed against complications from further enlargement of very large SCTs and against the risks of in utero intervention.",

keywords = "Prematurity, Sacrococcygeal teratoma, Survival",

author = "Holcroft, {Cynthia J.} and Blakemore, {Karin J.} and Gurewitsch, {Edith D.} and Driggers, {Rita W.} and Northington, {Frances J.} and Fischer, {Anne C.}",

year = "2008",

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doi = "10.1159/000132408",

language = "English (US)",

volume = "24",

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T2 - Could early delivery improve outcome?

AU - Holcroft, Cynthia J.

AU - Blakemore, Karin J.

AU - Gurewitsch, Edith D.

AU - Driggers, Rita W.

AU - Northington, Frances J.

AU - Fischer, Anne C.

PY - 2008/7

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N2 - Objective: To determine if gestational age (GA) at delivery or tumor size impacts outcome in neonates with very large sacrococcygeal teratomas (SCTs). Methods: Retrospective chart review from 1990 to 2006 of live-born infants with very large SCTs, defined as diameters exceeding 10 cm. Data analyzed using the independent t test and Fisher's exact test, with p values <0.05 considered significant. Results: Nine infants with very large SCTs were identified. Six of the 9 infants survived, 4 of whom had evidence of early hydrops. Mean GA of survivors was 32.2 ± 3.7 versus 31.7 ± 0.6 weeks in nonsurvivors (p = 0.85). Infants with the largest SCTs did not survive. Conclusion: Risks of preterm delivery must be weighed against complications from further enlargement of very large SCTs and against the risks of in utero intervention.

AB - Objective: To determine if gestational age (GA) at delivery or tumor size impacts outcome in neonates with very large sacrococcygeal teratomas (SCTs). Methods: Retrospective chart review from 1990 to 2006 of live-born infants with very large SCTs, defined as diameters exceeding 10 cm. Data analyzed using the independent t test and Fisher's exact test, with p values <0.05 considered significant. Results: Nine infants with very large SCTs were identified. Six of the 9 infants survived, 4 of whom had evidence of early hydrops. Mean GA of survivors was 32.2 ± 3.7 versus 31.7 ± 0.6 weeks in nonsurvivors (p = 0.85). Infants with the largest SCTs did not survive. Conclusion: Risks of preterm delivery must be weighed against complications from further enlargement of very large SCTs and against the risks of in utero intervention.

KW - Prematurity

KW - Sacrococcygeal teratoma

KW - Survival

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Large fetal sacrococcygeal teratomas: Could early delivery improve outcome?

Abstract

Keywords

ASJC Scopus subject areas

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