Langerhans cells utilize CD1a and langerin to efficiently present nonpeptide antigens to T cells

Robert E. Hunger, Peter A. Sieling, Maria Teresa Ochoa, Makoto Sugaya, Anne E. Burdick, Thomas H. Rea, Patrick J. Brennan, John T. Belisle, Andrew Blauvelt, Steven A. Porcelli, Robert L. Modlin

Research output: Contribution to journalArticle

212 Citations (Scopus)

Abstract

Langerhans cells (LCs) constitute a subset of DCs that initiate immune responses in skin. Using leprosy as a model, we investigated whether expression of CD1a and langerin, an LC-specific C-type lectin, imparts a specific functional role to LCs. LC-like DCs and freshly isolated epidermal LCs presented nonpeptide antigens of Mycobacterium leprae to T cell clones derived from a leprosy patient in a CD1a-restricted and langerin-dependent manner. LC-like DCs were more efficient at CD1a-restricted antigen presentation than monocyte-derived DCs. LCs in leprosy lesions coexpress CD1a and langerin, placing LCs in position to efficiently present a subset of antigens to T cells as part of the host response to human infectious disease.

Original languageEnglish (US)
Pages (from-to)701-708
Number of pages8
JournalJournal of Clinical Investigation
Volume113
Issue number5
DOIs
StatePublished - Mar 2004

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Langerhans Cells
T-Lymphocytes
Antigens
Leprosy
C-Type Lectins
Mycobacterium leprae
Antigen Presentation
Communicable Diseases
Monocytes
Clone Cells
Skin

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Hunger, R. E., Sieling, P. A., Ochoa, M. T., Sugaya, M., Burdick, A. E., Rea, T. H., ... Modlin, R. L. (2004). Langerhans cells utilize CD1a and langerin to efficiently present nonpeptide antigens to T cells. Journal of Clinical Investigation, 113(5), 701-708. https://doi.org/10.1172/JCI200419655

Langerhans cells utilize CD1a and langerin to efficiently present nonpeptide antigens to T cells. / Hunger, Robert E.; Sieling, Peter A.; Ochoa, Maria Teresa; Sugaya, Makoto; Burdick, Anne E.; Rea, Thomas H.; Brennan, Patrick J.; Belisle, John T.; Blauvelt, Andrew; Porcelli, Steven A.; Modlin, Robert L.

In: Journal of Clinical Investigation, Vol. 113, No. 5, 03.2004, p. 701-708.

Research output: Contribution to journalArticle

Hunger, RE, Sieling, PA, Ochoa, MT, Sugaya, M, Burdick, AE, Rea, TH, Brennan, PJ, Belisle, JT, Blauvelt, A, Porcelli, SA & Modlin, RL 2004, 'Langerhans cells utilize CD1a and langerin to efficiently present nonpeptide antigens to T cells', Journal of Clinical Investigation, vol. 113, no. 5, pp. 701-708. https://doi.org/10.1172/JCI200419655
Hunger, Robert E. ; Sieling, Peter A. ; Ochoa, Maria Teresa ; Sugaya, Makoto ; Burdick, Anne E. ; Rea, Thomas H. ; Brennan, Patrick J. ; Belisle, John T. ; Blauvelt, Andrew ; Porcelli, Steven A. ; Modlin, Robert L. / Langerhans cells utilize CD1a and langerin to efficiently present nonpeptide antigens to T cells. In: Journal of Clinical Investigation. 2004 ; Vol. 113, No. 5. pp. 701-708.
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