Langerhans cells utilize CD1a and langerin to efficiently present nonpeptide antigens to T cells

Robert E. Hunger; Peter A. Sieling; Maria Teresa Ochoa; Makoto Sugaya; Anne E. Burdick; Thomas H. Rea; Patrick J. Brennan; John T. Belisle; Andrew Blauvelt; Steven A. Porcelli; Robert L. Modlin

doi:10.1172/JCI200419655

Langerhans cells utilize CD1a and langerin to efficiently present nonpeptide antigens to T cells

Robert E. Hunger, Peter A. Sieling, Maria Teresa Ochoa, Makoto Sugaya, Anne E. Burdick, Thomas H. Rea, Patrick J. Brennan, John T. Belisle, Andrew Blauvelt, Steven A. Porcelli, Robert L. Modlin

Microbiology & Immunology

Research output: Contribution to journal › Article › peer-review

257 Scopus citations

Abstract

Langerhans cells (LCs) constitute a subset of DCs that initiate immune responses in skin. Using leprosy as a model, we investigated whether expression of CD1a and langerin, an LC-specific C-type lectin, imparts a specific functional role to LCs. LC-like DCs and freshly isolated epidermal LCs presented nonpeptide antigens of Mycobacterium leprae to T cell clones derived from a leprosy patient in a CD1a-restricted and langerin-dependent manner. LC-like DCs were more efficient at CD1a-restricted antigen presentation than monocyte-derived DCs. LCs in leprosy lesions coexpress CD1a and langerin, placing LCs in position to efficiently present a subset of antigens to T cells as part of the host response to human infectious disease.

Original language	English (US)
Pages (from-to)	701-708
Number of pages	8
Journal	Journal of Clinical Investigation
Volume	113
Issue number	5
DOIs	https://doi.org/10.1172/JCI200419655
State	Published - Mar 2004

ASJC Scopus subject areas

General Medicine

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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@article{124ede22b9894b6d8a9de6b34ee5e0d3,

title = "Langerhans cells utilize CD1a and langerin to efficiently present nonpeptide antigens to T cells",

abstract = "Langerhans cells (LCs) constitute a subset of DCs that initiate immune responses in skin. Using leprosy as a model, we investigated whether expression of CD1a and langerin, an LC-specific C-type lectin, imparts a specific functional role to LCs. LC-like DCs and freshly isolated epidermal LCs presented nonpeptide antigens of Mycobacterium leprae to T cell clones derived from a leprosy patient in a CD1a-restricted and langerin-dependent manner. LC-like DCs were more efficient at CD1a-restricted antigen presentation than monocyte-derived DCs. LCs in leprosy lesions coexpress CD1a and langerin, placing LCs in position to efficiently present a subset of antigens to T cells as part of the host response to human infectious disease.",

author = "Hunger, {Robert E.} and Sieling, {Peter A.} and Ochoa, {Maria Teresa} and Makoto Sugaya and Burdick, {Anne E.} and Rea, {Thomas H.} and Brennan, {Patrick J.} and Belisle, {John T.} and Andrew Blauvelt and Porcelli, {Steven A.} and Modlin, {Robert L.}",

year = "2004",

month = mar,

doi = "10.1172/JCI200419655",

language = "English (US)",

volume = "113",

pages = "701--708",

journal = "Journal of Clinical Investigation",

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T1 - Langerhans cells utilize CD1a and langerin to efficiently present nonpeptide antigens to T cells

AU - Hunger, Robert E.

AU - Sieling, Peter A.

AU - Ochoa, Maria Teresa

AU - Sugaya, Makoto

AU - Burdick, Anne E.

AU - Rea, Thomas H.

AU - Brennan, Patrick J.

AU - Belisle, John T.

AU - Blauvelt, Andrew

AU - Porcelli, Steven A.

AU - Modlin, Robert L.

PY - 2004/3

Y1 - 2004/3

N2 - Langerhans cells (LCs) constitute a subset of DCs that initiate immune responses in skin. Using leprosy as a model, we investigated whether expression of CD1a and langerin, an LC-specific C-type lectin, imparts a specific functional role to LCs. LC-like DCs and freshly isolated epidermal LCs presented nonpeptide antigens of Mycobacterium leprae to T cell clones derived from a leprosy patient in a CD1a-restricted and langerin-dependent manner. LC-like DCs were more efficient at CD1a-restricted antigen presentation than monocyte-derived DCs. LCs in leprosy lesions coexpress CD1a and langerin, placing LCs in position to efficiently present a subset of antigens to T cells as part of the host response to human infectious disease.

AB - Langerhans cells (LCs) constitute a subset of DCs that initiate immune responses in skin. Using leprosy as a model, we investigated whether expression of CD1a and langerin, an LC-specific C-type lectin, imparts a specific functional role to LCs. LC-like DCs and freshly isolated epidermal LCs presented nonpeptide antigens of Mycobacterium leprae to T cell clones derived from a leprosy patient in a CD1a-restricted and langerin-dependent manner. LC-like DCs were more efficient at CD1a-restricted antigen presentation than monocyte-derived DCs. LCs in leprosy lesions coexpress CD1a and langerin, placing LCs in position to efficiently present a subset of antigens to T cells as part of the host response to human infectious disease.

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Langerhans cells utilize CD1a and langerin to efficiently present nonpeptide antigens to T cells

Abstract

ASJC Scopus subject areas

UN SDGs

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