Laminar analysis of bicuculline-induced epileptiform activity in area 17 of the awake macaque

C. E. Schroeder, C. E. Tenke, S. J. Givre, J. C. Arezzo, H. G. Vaughan

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Abstract

We investigated the laminar profile of visually evoked paroxysmal discharge following bicuculline administration in area 17 of the alert macaque. Paroxysmal discharge was focussed in lamina 3, with lesser concomitants in infragranular laminae. There were no marked effects on the flash-evoked laminar activation sequence. The neocortex of the alert macaque studied with the present techniques may provide a model for evaluating basic mechanisms of epilepsy, and for linking these to the macroscopic phenomena seen in humans.

Original languageEnglish (US)
Pages (from-to)326-330
Number of pages5
JournalBrain Research
Volume515
Issue number1-2
DOIs
Publication statusPublished - May 7 1990

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Keywords

  • Alert macaque
  • Bicuculline
  • Current source density
  • Epilepsy
  • Multiunit activity
  • Striate cortex
  • Visual evoked potential

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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