Laminar analysis of bicuculline-induced epileptiform activity in area 17 of the awake macaque

C. E. Schroeder; C. E. Tenke; S. J. Givre; J. C. Arezzo; H. G. Vaughan

doi:10.1016/0006-8993(90)90617-K

Laminar analysis of bicuculline-induced epileptiform activity in area 17 of the awake macaque

C. E. Schroeder, C. E. Tenke, S. J. Givre, J. C. Arezzo, H. G. Vaughan

Neuroscience

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Abstract

We investigated the laminar profile of visually evoked paroxysmal discharge following bicuculline administration in area 17 of the alert macaque. Paroxysmal discharge was focussed in lamina 3, with lesser concomitants in infragranular laminae. There were no marked effects on the flash-evoked laminar activation sequence. The neocortex of the alert macaque studied with the present techniques may provide a model for evaluating basic mechanisms of epilepsy, and for linking these to the macroscopic phenomena seen in humans.

Original language	English (US)
Pages (from-to)	326-330
Number of pages	5
Journal	Brain research
Volume	515
Issue number	1-2
DOIs	https://doi.org/10.1016/0006-8993(90)90617-K
State	Published - May 7 1990

Keywords

Alert macaque
Bicuculline
Current source density
Epilepsy
Multiunit activity
Striate cortex
Visual evoked potential

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(90)90617-K

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title = "Laminar analysis of bicuculline-induced epileptiform activity in area 17 of the awake macaque",

abstract = "We investigated the laminar profile of visually evoked paroxysmal discharge following bicuculline administration in area 17 of the alert macaque. Paroxysmal discharge was focussed in lamina 3, with lesser concomitants in infragranular laminae. There were no marked effects on the flash-evoked laminar activation sequence. The neocortex of the alert macaque studied with the present techniques may provide a model for evaluating basic mechanisms of epilepsy, and for linking these to the macroscopic phenomena seen in humans.",

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AU - Schroeder, C. E.

AU - Tenke, C. E.

AU - Givre, S. J.

AU - Arezzo, J. C.

AU - Vaughan, H. G.

PY - 1990/5/7

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N2 - We investigated the laminar profile of visually evoked paroxysmal discharge following bicuculline administration in area 17 of the alert macaque. Paroxysmal discharge was focussed in lamina 3, with lesser concomitants in infragranular laminae. There were no marked effects on the flash-evoked laminar activation sequence. The neocortex of the alert macaque studied with the present techniques may provide a model for evaluating basic mechanisms of epilepsy, and for linking these to the macroscopic phenomena seen in humans.

AB - We investigated the laminar profile of visually evoked paroxysmal discharge following bicuculline administration in area 17 of the alert macaque. Paroxysmal discharge was focussed in lamina 3, with lesser concomitants in infragranular laminae. There were no marked effects on the flash-evoked laminar activation sequence. The neocortex of the alert macaque studied with the present techniques may provide a model for evaluating basic mechanisms of epilepsy, and for linking these to the macroscopic phenomena seen in humans.

KW - Alert macaque

KW - Bicuculline

KW - Current source density

KW - Epilepsy

KW - Multiunit activity

KW - Striate cortex

KW - Visual evoked potential

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Laminar analysis of bicuculline-induced epileptiform activity in area 17 of the awake macaque

Abstract

Keywords

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