Lamellipodia in invasion

John S. Condeelis, Jeffrey B. Wyckoff, Maryse Bailly, Richard Pestell, David Lawrence, Jonathan Backer, Jeffrey E. Segall

Research output: Contribution to journalArticle

107 Scopus citations

Abstract

In vivo imaging of GFP-labeled metastatic tumor cells reveals cell orientation towards blood vessels. Orientation of tumor cells during chemotactic responses to ligands such as EGF begins with lamellipod extension. Evaluation of some of the downstream events in lamellipod extension indicates: (1) plasma membrane distribution of the EGF receptor is uniform but internalized receptor accumulates on the side of the cell closest to the source of EGF; (2) the alpha p110 isoform of PI-3 kinase is required; and (3) protrusion of the lamellipod relies upon the combined actions of the Arp2/3 complex and cofilin for generation of filamentous actin.

Original languageEnglish (US)
Pages (from-to)119-128
Number of pages10
JournalSeminars in Cancer Biology
Volume11
Issue number2
DOIs
StatePublished - Jan 1 2001

Keywords

  • Arp2/3
  • Cofilin
  • EGF receptor
  • Lamellipod
  • Pi 3-kinase

ASJC Scopus subject areas

  • Cancer Research

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