Lamellipodia in invasion

John S. Condeelis; Jeffrey B. Wyckoff; Maryse Bailly; Richard Pestell; David Lawrence; Jonathan Backer; Jeffrey E. Segall

doi:10.1006/scbi.2000.0363

Lamellipodia in invasion

John S. Condeelis, Jeffrey B. Wyckoff, Maryse Bailly, Richard Pestell, David Lawrence, Jonathan Backer, Jeffrey E. Segall

Research output: Contribution to journal › Article › peer-review

117 Scopus citations

Abstract

In vivo imaging of GFP-labeled metastatic tumor cells reveals cell orientation towards blood vessels. Orientation of tumor cells during chemotactic responses to ligands such as EGF begins with lamellipod extension. Evaluation of some of the downstream events in lamellipod extension indicates: (1) plasma membrane distribution of the EGF receptor is uniform but internalized receptor accumulates on the side of the cell closest to the source of EGF; (2) the alpha p110 isoform of PI-3 kinase is required; and (3) protrusion of the lamellipod relies upon the combined actions of the Arp2/3 complex and cofilin for generation of filamentous actin.

Original language	English (US)
Pages (from-to)	119-128
Number of pages	10
Journal	Seminars in Cancer Biology
Volume	11
Issue number	2
DOIs	https://doi.org/10.1006/scbi.2000.0363
State	Published - 2001

Keywords

Arp2/3
Cofilin
EGF receptor
Lamellipod
Pi 3-kinase

ASJC Scopus subject areas

Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1006/scbi.2000.0363

Cite this

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title = "Lamellipodia in invasion",

abstract = "In vivo imaging of GFP-labeled metastatic tumor cells reveals cell orientation towards blood vessels. Orientation of tumor cells during chemotactic responses to ligands such as EGF begins with lamellipod extension. Evaluation of some of the downstream events in lamellipod extension indicates: (1) plasma membrane distribution of the EGF receptor is uniform but internalized receptor accumulates on the side of the cell closest to the source of EGF; (2) the alpha p110 isoform of PI-3 kinase is required; and (3) protrusion of the lamellipod relies upon the combined actions of the Arp2/3 complex and cofilin for generation of filamentous actin.",

keywords = "Arp2/3, Cofilin, EGF receptor, Lamellipod, Pi 3-kinase",

author = "Condeelis, {John S.} and Wyckoff, {Jeffrey B.} and Maryse Bailly and Richard Pestell and David Lawrence and Jonathan Backer and Segall, {Jeffrey E.}",

note = "Funding Information: Movies of movement of metastatic tumor cells can be viewed at http://www.aecom.yu.edu/asb/segall/ segall.htm. Funding for the work described here was supported by grants from the Department of Defense Breast Cancer Program and the National Institutes of Health.",

year = "2001",

doi = "10.1006/scbi.2000.0363",

language = "English (US)",

volume = "11",

pages = "119--128",

journal = "Seminars in Cancer Biology",

issn = "1044-579X",

publisher = "Academic Press Inc.",

number = "2",

}

TY - JOUR

T1 - Lamellipodia in invasion

AU - Condeelis, John S.

AU - Wyckoff, Jeffrey B.

AU - Bailly, Maryse

AU - Pestell, Richard

AU - Lawrence, David

AU - Backer, Jonathan

AU - Segall, Jeffrey E.

N1 - Funding Information: Movies of movement of metastatic tumor cells can be viewed at http://www.aecom.yu.edu/asb/segall/ segall.htm. Funding for the work described here was supported by grants from the Department of Defense Breast Cancer Program and the National Institutes of Health.

PY - 2001

Y1 - 2001

N2 - In vivo imaging of GFP-labeled metastatic tumor cells reveals cell orientation towards blood vessels. Orientation of tumor cells during chemotactic responses to ligands such as EGF begins with lamellipod extension. Evaluation of some of the downstream events in lamellipod extension indicates: (1) plasma membrane distribution of the EGF receptor is uniform but internalized receptor accumulates on the side of the cell closest to the source of EGF; (2) the alpha p110 isoform of PI-3 kinase is required; and (3) protrusion of the lamellipod relies upon the combined actions of the Arp2/3 complex and cofilin for generation of filamentous actin.

AB - In vivo imaging of GFP-labeled metastatic tumor cells reveals cell orientation towards blood vessels. Orientation of tumor cells during chemotactic responses to ligands such as EGF begins with lamellipod extension. Evaluation of some of the downstream events in lamellipod extension indicates: (1) plasma membrane distribution of the EGF receptor is uniform but internalized receptor accumulates on the side of the cell closest to the source of EGF; (2) the alpha p110 isoform of PI-3 kinase is required; and (3) protrusion of the lamellipod relies upon the combined actions of the Arp2/3 complex and cofilin for generation of filamentous actin.

KW - Arp2/3

KW - Cofilin

KW - EGF receptor

KW - Lamellipod

KW - Pi 3-kinase

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DO - 10.1006/scbi.2000.0363

M3 - Article

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AN - SCOPUS:0035024880

SN - 1044-579X

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SP - 119

EP - 128

JO - Seminars in Cancer Biology

JF - Seminars in Cancer Biology

IS - 2

ER -

Lamellipodia in invasion

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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