Lamellar fibrosis in the fibrolamellar variant of hepatocellular carcinoma: A role for transforming growth factor beta

Giulia Orsatti, Prodromos Hytiroglou, Swan N. Thung, Kamal G. Ishak, Fiorenzo Paronetto

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Transforming growth factor-beta (TGF-β) is a pluripotent regulatory molecule, found in at least five different isoforms. It is produced in many different organs. In the liver, TGF-β is expressed in non-parenchymal cells, but not in hepatocytes. This growth factor is known to induce fibrosis in the course of a variety of pathologic processes. Recently, TGF-β has also been identified in hepatocellular carcinoma (HCC) cells, and the suggestion has been made that this growth factor may play a role in hepatocarcinogenesis. In this study, we report the findings of immunohistochemical stains for TGF-β, performed on paraffin sections of 14 human HCCs of the usual type and 11 examples of the fibrolamellar variant (FLC). TGF-β was detected in tumor cells of 3 HCCs (21%) and 9 FLCs (82%). Compared with the HCCs, the FLCs displayed a more diffuse and intense staining pattern for TGF-β. Our findings suggest that lamellar fibrosis, which is a histologic hallmark of FLC, may be due to the action of TGF-β produced by tumor cells.

Original languageEnglish (US)
Pages (from-to)152-156
Number of pages5
JournalLiver
Volume17
Issue number3
StatePublished - Jun 1997
Externally publishedYes

Fingerprint

Transforming Growth Factor beta
Fibrosis
Intercellular Signaling Peptides and Proteins
Pathologic Processes
Fibrolamellar hepatocellular carcinoma
Paraffin
Hepatocytes
Hepatocellular Carcinoma
Neoplasms
Protein Isoforms
Coloring Agents
Staining and Labeling
Liver

Keywords

  • Cancer
  • Carcinoma
  • Fibrolamellar carcinoma
  • Fibrosis-growth factor
  • Hepatocellular carcinoma
  • Hepatoma
  • Immunohistochemistry
  • Liver
  • TGF-β

ASJC Scopus subject areas

  • Hepatology

Cite this

Orsatti, G., Hytiroglou, P., Thung, S. N., Ishak, K. G., & Paronetto, F. (1997). Lamellar fibrosis in the fibrolamellar variant of hepatocellular carcinoma: A role for transforming growth factor beta. Liver, 17(3), 152-156.

Lamellar fibrosis in the fibrolamellar variant of hepatocellular carcinoma : A role for transforming growth factor beta. / Orsatti, Giulia; Hytiroglou, Prodromos; Thung, Swan N.; Ishak, Kamal G.; Paronetto, Fiorenzo.

In: Liver, Vol. 17, No. 3, 06.1997, p. 152-156.

Research output: Contribution to journalArticle

Orsatti, G, Hytiroglou, P, Thung, SN, Ishak, KG & Paronetto, F 1997, 'Lamellar fibrosis in the fibrolamellar variant of hepatocellular carcinoma: A role for transforming growth factor beta', Liver, vol. 17, no. 3, pp. 152-156.
Orsatti G, Hytiroglou P, Thung SN, Ishak KG, Paronetto F. Lamellar fibrosis in the fibrolamellar variant of hepatocellular carcinoma: A role for transforming growth factor beta. Liver. 1997 Jun;17(3):152-156.
Orsatti, Giulia ; Hytiroglou, Prodromos ; Thung, Swan N. ; Ishak, Kamal G. ; Paronetto, Fiorenzo. / Lamellar fibrosis in the fibrolamellar variant of hepatocellular carcinoma : A role for transforming growth factor beta. In: Liver. 1997 ; Vol. 17, No. 3. pp. 152-156.
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