LAG-3 is expressed on a majority of tumor infiltrating lymphocytes in pediatric Hodgkin lymphoma

Scott Moerdler, Michelle Ewart, Debra L. Friedman, Kara Kelly, Qinglin Pei, Mou Peng, Xing Xing Zang, Peter D. Cole

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

LAG-3, through interaction with a variety of ligands, regulates T cell function via inhibition of T cell proliferation and activation. It has been demonstrated to be overexpressed on tumor infiltrating lymphocytes (TILs) of a variety of cancers with associated poor outcomes. The purpose of this study is to characterize the expression pattern and clinical significance of LAG-3 in pediatric Hodgkin lymphoma (HL). Patient tumor samples from Children’s Oncology Group clinical trial AHOD0031 with matched patient outcome data were analyzed for the expression of LAG-3 and PD-L1 using immunohistochemistry. 73/115 patients (63%) demonstrated positive LAG-3 staining. No demographic or survival outcome data were significantly associated with LAG-3 expression. Interestingly, patients with the lowest density of expression were found to have the worst EFS, and those with highest density of expression demonstrated the best EFS. There was a positive statistically significant relationship between presence of LAG-3 and PD-L1 expression. This project is innovative in its characterization of LAG-3 as an immune checkpoint target in pediatric HL.

Original languageEnglish (US)
Pages (from-to)606-613
Number of pages8
JournalLeukemia and Lymphoma
Volume62
Issue number3
DOIs
StatePublished - 2021

Keywords

  • LAG-3
  • Pediatric Hodgkin lymphoma
  • immune checkpoint
  • immunotherapy

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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