Lactic acidosis in severe asthma

David Appel, Roy Rubenstein, Kenneth Schrager, M. Henry Williams

Research output: Contribution to journalArticle

66 Scopus citations


Twelve patients with severe asthma in whom lactic acidosis developed are presented. All had an arterial blood pH level lower than that expected for the measured partial pressure of arterial carbon dioxide, all had an abnormally large anion gap, and the blood lactate level exceeded 2.8 mmol/liter. Respiratory acidosis subsequently developed in eight patients, and six required intubation. Lactic acidosis can develop in patients with severe asthma. Such patients are in danger of the development of respiratory failure and must be treated vigorously and observed closely.

Original languageEnglish (US)
Pages (from-to)580-584
Number of pages5
JournalThe American Journal of Medicine
Issue number4
Publication statusPublished - Oct 1983
Externally publishedYes


ASJC Scopus subject areas

  • Medicine(all)

Cite this

Appel, D., Rubenstein, R., Schrager, K., & Williams, M. H. (1983). Lactic acidosis in severe asthma. The American Journal of Medicine, 75(4), 580-584.