Lactate turnover at rest and during submaximal exercise in patients with heart failure

S. D. Katz, B. Bleiberg, J. Wexler, K. Bhargava, J. J. Steinberg, T. H. LeJemtel

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Systemic and lower limb skeletal muscle lactate metabolism was studied in 10 men with congestive heart failure by use of a primed continuous intravenous infusion of L-(+)-[U-14C]lactate. Arterial and deep femoral venous blood samples were obtained at rest and during 30 min of submaximal exercise. Systemic lactate metabolic turnover rate (Rd) was determined using Steele's isotopic steady-state equation (Rd = isotopic infusion rate/arterial specific activity). Plasma lactate concentrations in the artery and deep femoral vein did not change significantly from resting values during exercise (1.11 ± 0.13 vs. 1.26 ± 0.12 and 1.27 ± 0.12 vs. 1.30 ± 0.12 mM, respectively), whereas Rd increased from 22.5 ± 1.8 to 41.6 ± 4.8 μmol · kg-1 · min-1 (P < 0.005). Rd did not significantly correlate with arterial lactate concentration during rest or exercise. Because of simultaneous uptake and release of lactate in skeletal muscle, arterial and deep femoral venous lactate concentrations are not closely related to either systemic or lower limb skeletal muscle lactate metabolism in patients with congestive heart failure.

Original languageEnglish (US)
Pages (from-to)1974-1979
Number of pages6
JournalJournal of Applied Physiology
Volume75
Issue number5
StatePublished - Jan 1 1993

Keywords

  • lactate kinetics
  • skeletal muscle metabolism

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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    Katz, S. D., Bleiberg, B., Wexler, J., Bhargava, K., Steinberg, J. J., & LeJemtel, T. H. (1993). Lactate turnover at rest and during submaximal exercise in patients with heart failure. Journal of Applied Physiology, 75(5), 1974-1979.