Lack of interferon γ receptor β chain and the prevention of interferon γ signaling in TH1 Cells

Alessandra Pernis, Sanjay Gupta, Kenneth J. Gollob, Evan Garfein, Robert L. Coffman, Chris Schindler, Paul Rothman

Research output: Contribution to journalArticle

269 Scopus citations

Abstract

The ability of interferon γ (IFN-γ) to inhibit the proliferation of type 2 T helper cells (TH2), but not that of type 1 (TH1) cells, suggests that helper cell subsets might differ in their activation of the IFN-γ signaling pathway. The IFN-γ-inducible signal transducing factor (STF-IFNγ) was activated in murine T H2 but not in TH1 cell clones, because in the latter the second chain of the IFN-γ receptor (accessory factor 1 or IFN-γRβ) was absent. Thus, TH1 cells use receptor modification to prevent the activation of STF-IFNγ and achieve an IFN-γ-resistant state.

Original languageEnglish (US)
Pages (from-to)245-247
Number of pages3
JournalScience
Volume269
Issue number5221
DOIs
StatePublished - Jan 1 1995
Externally publishedYes

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    Pernis, A., Gupta, S., Gollob, K. J., Garfein, E., Coffman, R. L., Schindler, C., & Rothman, P. (1995). Lack of interferon γ receptor β chain and the prevention of interferon γ signaling in TH1 Cells. Science, 269(5221), 245-247. https://doi.org/10.1126/science.7618088