Lack of interferon γ receptor β chain and the prevention of interferon γ signaling in TH1 cells

Alessandra Pernis, Sanjay Gupta, Kenneth J. Gollob, Evan S. Garfein, Robert L. Coffman, Chris Schindler, Paul Rothman

Research output: Contribution to journalArticle

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Abstract

The ability of interferon γ (IFN-γ) to inhibit the proliferation of type 2 T helper cells (TH2), but not that of type 1 (TH1) cells, suggests that helper cell subsets might differ in their activation of the IFN-γ signaling pathway. The IFN-γ-inducible signal transducing factor (STF-IFNγ) was activated in murine TH2 but not in TH1 cell clones, because in the latter the second chain of the IFN-γ receptor (accessory factor 1 or IFN-γRβ) was absent. Thus, TH1 cells use receptor modification to prevent the activation of STF-IFN-γ and achieve an IFN-γ-resistant state.

Original languageEnglish (US)
Pages (from-to)245-247
Number of pages3
JournalScience
Volume269
Issue number5221
StatePublished - Jul 14 1995
Externally publishedYes

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Interferon Receptors
Interferons
Th2 Cells
Helper-Inducer T-Lymphocytes
Clone Cells

ASJC Scopus subject areas

  • General

Cite this

Pernis, A., Gupta, S., Gollob, K. J., Garfein, E. S., Coffman, R. L., Schindler, C., & Rothman, P. (1995). Lack of interferon γ receptor β chain and the prevention of interferon γ signaling in TH1 cells. Science, 269(5221), 245-247.

Lack of interferon γ receptor β chain and the prevention of interferon γ signaling in TH1 cells. / Pernis, Alessandra; Gupta, Sanjay; Gollob, Kenneth J.; Garfein, Evan S.; Coffman, Robert L.; Schindler, Chris; Rothman, Paul.

In: Science, Vol. 269, No. 5221, 14.07.1995, p. 245-247.

Research output: Contribution to journalArticle

Pernis, A, Gupta, S, Gollob, KJ, Garfein, ES, Coffman, RL, Schindler, C & Rothman, P 1995, 'Lack of interferon γ receptor β chain and the prevention of interferon γ signaling in TH1 cells', Science, vol. 269, no. 5221, pp. 245-247.
Pernis A, Gupta S, Gollob KJ, Garfein ES, Coffman RL, Schindler C et al. Lack of interferon γ receptor β chain and the prevention of interferon γ signaling in TH1 cells. Science. 1995 Jul 14;269(5221):245-247.
Pernis, Alessandra ; Gupta, Sanjay ; Gollob, Kenneth J. ; Garfein, Evan S. ; Coffman, Robert L. ; Schindler, Chris ; Rothman, Paul. / Lack of interferon γ receptor β chain and the prevention of interferon γ signaling in TH1 cells. In: Science. 1995 ; Vol. 269, No. 5221. pp. 245-247.
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