Lack of heterogeneity of HPV16 E7 sequence compared with HPV31 and HPV73 may be related to its unique carcinogenic properties

Mahboobeh Safaeian, Koenraad van Doorslaer, Mark Schiffman, Zigui Chen, Ana Cecilia Rodriguez, Rolando Herrero, Allan Hildesheim, Robert D. Burk

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

To assess the role of human papillomavirus virus (HPV) genetics in cervical lesions, we sequenced the E7 gene of HPV16, 31, or 73 from singly infected women who (1) cleared the infection quickly, (2) had type-specific persistent infection, or (3) progressed to CIN2 or worse lesions. Four of the 296 HPV16 E7 nucleotides were variable, compared with 7 of 296 for HPV31 E7 and 4 of 296 for HPV73 E7. While most of the polymorphisms in HPV31 and -73 resulted in non-synonymous amino acid changes, the polymorphisms in the HPV16 E7 resulted in synonymous changes. The lack of heterogeneity of HPV16 E7 suggests high evolutionary purifying selection that might be related to the unique carcinogenicity of HPV16.

Original languageEnglish (US)
Pages (from-to)367-370
Number of pages4
JournalArchives of Virology
Volume155
Issue number3
DOIs
StatePublished - Mar 2010

Fingerprint

Papillomaviridae
Infection
Nucleotides
Amino Acids
Genes

ASJC Scopus subject areas

  • Virology

Cite this

Lack of heterogeneity of HPV16 E7 sequence compared with HPV31 and HPV73 may be related to its unique carcinogenic properties. / Safaeian, Mahboobeh; van Doorslaer, Koenraad; Schiffman, Mark; Chen, Zigui; Rodriguez, Ana Cecilia; Herrero, Rolando; Hildesheim, Allan; Burk, Robert D.

In: Archives of Virology, Vol. 155, No. 3, 03.2010, p. 367-370.

Research output: Contribution to journalArticle

Safaeian, M, van Doorslaer, K, Schiffman, M, Chen, Z, Rodriguez, AC, Herrero, R, Hildesheim, A & Burk, RD 2010, 'Lack of heterogeneity of HPV16 E7 sequence compared with HPV31 and HPV73 may be related to its unique carcinogenic properties', Archives of Virology, vol. 155, no. 3, pp. 367-370. https://doi.org/10.1007/s00705-009-0579-2
Safaeian, Mahboobeh ; van Doorslaer, Koenraad ; Schiffman, Mark ; Chen, Zigui ; Rodriguez, Ana Cecilia ; Herrero, Rolando ; Hildesheim, Allan ; Burk, Robert D. / Lack of heterogeneity of HPV16 E7 sequence compared with HPV31 and HPV73 may be related to its unique carcinogenic properties. In: Archives of Virology. 2010 ; Vol. 155, No. 3. pp. 367-370.
@article{81b2055d7b58481f9f4647a542eb1bf4,
title = "Lack of heterogeneity of HPV16 E7 sequence compared with HPV31 and HPV73 may be related to its unique carcinogenic properties",
abstract = "To assess the role of human papillomavirus virus (HPV) genetics in cervical lesions, we sequenced the E7 gene of HPV16, 31, or 73 from singly infected women who (1) cleared the infection quickly, (2) had type-specific persistent infection, or (3) progressed to CIN2 or worse lesions. Four of the 296 HPV16 E7 nucleotides were variable, compared with 7 of 296 for HPV31 E7 and 4 of 296 for HPV73 E7. While most of the polymorphisms in HPV31 and -73 resulted in non-synonymous amino acid changes, the polymorphisms in the HPV16 E7 resulted in synonymous changes. The lack of heterogeneity of HPV16 E7 suggests high evolutionary purifying selection that might be related to the unique carcinogenicity of HPV16.",
author = "Mahboobeh Safaeian and {van Doorslaer}, Koenraad and Mark Schiffman and Zigui Chen and Rodriguez, {Ana Cecilia} and Rolando Herrero and Allan Hildesheim and Burk, {Robert D.}",
year = "2010",
month = "3",
doi = "10.1007/s00705-009-0579-2",
language = "English (US)",
volume = "155",
pages = "367--370",
journal = "Archives of Virology",
issn = "0304-8608",
publisher = "Springer Wien",
number = "3",

}

TY - JOUR

T1 - Lack of heterogeneity of HPV16 E7 sequence compared with HPV31 and HPV73 may be related to its unique carcinogenic properties

AU - Safaeian, Mahboobeh

AU - van Doorslaer, Koenraad

AU - Schiffman, Mark

AU - Chen, Zigui

AU - Rodriguez, Ana Cecilia

AU - Herrero, Rolando

AU - Hildesheim, Allan

AU - Burk, Robert D.

PY - 2010/3

Y1 - 2010/3

N2 - To assess the role of human papillomavirus virus (HPV) genetics in cervical lesions, we sequenced the E7 gene of HPV16, 31, or 73 from singly infected women who (1) cleared the infection quickly, (2) had type-specific persistent infection, or (3) progressed to CIN2 or worse lesions. Four of the 296 HPV16 E7 nucleotides were variable, compared with 7 of 296 for HPV31 E7 and 4 of 296 for HPV73 E7. While most of the polymorphisms in HPV31 and -73 resulted in non-synonymous amino acid changes, the polymorphisms in the HPV16 E7 resulted in synonymous changes. The lack of heterogeneity of HPV16 E7 suggests high evolutionary purifying selection that might be related to the unique carcinogenicity of HPV16.

AB - To assess the role of human papillomavirus virus (HPV) genetics in cervical lesions, we sequenced the E7 gene of HPV16, 31, or 73 from singly infected women who (1) cleared the infection quickly, (2) had type-specific persistent infection, or (3) progressed to CIN2 or worse lesions. Four of the 296 HPV16 E7 nucleotides were variable, compared with 7 of 296 for HPV31 E7 and 4 of 296 for HPV73 E7. While most of the polymorphisms in HPV31 and -73 resulted in non-synonymous amino acid changes, the polymorphisms in the HPV16 E7 resulted in synonymous changes. The lack of heterogeneity of HPV16 E7 suggests high evolutionary purifying selection that might be related to the unique carcinogenicity of HPV16.

UR - http://www.scopus.com/inward/record.url?scp=77949893867&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77949893867&partnerID=8YFLogxK

U2 - 10.1007/s00705-009-0579-2

DO - 10.1007/s00705-009-0579-2

M3 - Article

VL - 155

SP - 367

EP - 370

JO - Archives of Virology

JF - Archives of Virology

SN - 0304-8608

IS - 3

ER -