TY - JOUR
T1 - Laboratory Diagnosis of HTLV-1-Associated Myelopathy
AU - Rolon, Rebecca M.Marrero
AU - Yao, Joseph D.C.
N1 - Publisher Copyright:
© 2020 Elsevier Inc.
PY - 2020/8/15
Y1 - 2020/8/15
N2 - Human T-lymphotropic virus type 1 (HTLV-1), a human retrovirus, is endemic in certain regions of the world and affects millions of people worldwide. Infected individuals are at risk of developing adult T-cell leukemia/lymphoma and HTLV-1-associated myelopathy/tropical spastic paraparesis. Vertical and parenteral transmission are the main routes of infection. Diagnosis of HTLV-1 infection can be made by detection of HTLV-1-specific antibodies in plasma, serum, or cerebrospinal fluid using a combination of initial and supplemental serologic assays. In contrast, quantitative proviral DNA in peripheral blood mononuclear cells has been used to predict and monitor disease progression. This review provides an overview of the virology, epidemiology, transmission, pathophysiology, clinical manifestations, and laboratory testing methods for HTLV-1 infection.
AB - Human T-lymphotropic virus type 1 (HTLV-1), a human retrovirus, is endemic in certain regions of the world and affects millions of people worldwide. Infected individuals are at risk of developing adult T-cell leukemia/lymphoma and HTLV-1-associated myelopathy/tropical spastic paraparesis. Vertical and parenteral transmission are the main routes of infection. Diagnosis of HTLV-1 infection can be made by detection of HTLV-1-specific antibodies in plasma, serum, or cerebrospinal fluid using a combination of initial and supplemental serologic assays. In contrast, quantitative proviral DNA in peripheral blood mononuclear cells has been used to predict and monitor disease progression. This review provides an overview of the virology, epidemiology, transmission, pathophysiology, clinical manifestations, and laboratory testing methods for HTLV-1 infection.
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U2 - 10.1016/j.clinmicnews.2020.07.004
DO - 10.1016/j.clinmicnews.2020.07.004
M3 - Article
AN - SCOPUS:85089175680
SN - 0196-4399
VL - 42
SP - 129
EP - 134
JO - Clinical Microbiology Newsletter
JF - Clinical Microbiology Newsletter
IS - 16
ER -