Aptamers that bind to prostate specific membrane antigen (PSMA) were conjugated to luminescent CdSe and CdTe nanocrystals for cell-labeling studies. The aptamer-nanocrystal conjugates showed specific targeting of both fixed and live cells that overexpressed PSMA. More importantly, aptamers were able to label cells dispersed in a collagen gel matrix simulating tissue. The specific binding abilities and synthetic accessibility of aptamers combined with the photostability and small size of semiconductor nanocrystals offers a powerful and general tool for cellular imaging.
|Original language||English (US)|
|Number of pages||8|
|Journal||Biosensors and Bioelectronics|
|State||Published - Apr 15 2006|
- Cell imaging
ASJC Scopus subject areas
- Biomedical Engineering