Abstract
Aptamers that bind to prostate specific membrane antigen (PSMA) were conjugated to luminescent CdSe and CdTe nanocrystals for cell-labeling studies. The aptamer-nanocrystal conjugates showed specific targeting of both fixed and live cells that overexpressed PSMA. More importantly, aptamers were able to label cells dispersed in a collagen gel matrix simulating tissue. The specific binding abilities and synthetic accessibility of aptamers combined with the photostability and small size of semiconductor nanocrystals offers a powerful and general tool for cellular imaging.
Original language | English (US) |
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Pages (from-to) | 1859-1866 |
Number of pages | 8 |
Journal | Biosensors and Bioelectronics |
Volume | 21 |
Issue number | 10 |
DOIs | |
State | Published - Apr 15 2006 |
Externally published | Yes |
Keywords
- Aptamer
- Cell imaging
- Nanocrystal
ASJC Scopus subject areas
- Biotechnology
- Biophysics
- Biomedical Engineering
- Electrochemistry