Labeled putrescine as a probe in brain tumors

Nora Volkow; Stephen S. Goldman; Eugene S. Flamm; Humberto Cravioto; Alfred P. Wolf; Jonathan D. Brodie

doi:10.1126/science.6603020

Labeled putrescine as a probe in brain tumors

Nora Volkow, Stephen S. Goldman, Eugene S. Flamm, Humberto Cravioto, Alfred P. Wolf, Jonathan D. Brodie

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Abstract

The polyamine metabolism of transplanted N-nitrosomethylurea-derived rat glioma was determined with radiolabeled putrescine used as a marker for malignancy. The uptake of putrescine in vivo was complete within 5 minutes and was specific for tumor tissue. The conversion of putrescine to spermine and other metabolites by the tumor was rapid, in contrast to the case for adjacent normal brain. These results suggest that putrescine labeled with carbon-11 may be used as a positron-emission tomographic tracer for the selective metabolic imaging of brain tumor and may be used in an appropriate model as a marker for tumor growth rate.

Original language	English (US)
Pages (from-to)	673-675
Number of pages	3
Journal	Science
Volume	221
Issue number	4611
DOIs	https://doi.org/10.1126/science.6603020
State	Published - 1983
Externally published	Yes

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title = "Labeled putrescine as a probe in brain tumors",

abstract = "The polyamine metabolism of transplanted N-nitrosomethylurea-derived rat glioma was determined with radiolabeled putrescine used as a marker for malignancy. The uptake of putrescine in vivo was complete within 5 minutes and was specific for tumor tissue. The conversion of putrescine to spermine and other metabolites by the tumor was rapid, in contrast to the case for adjacent normal brain. These results suggest that putrescine labeled with carbon-11 may be used as a positron-emission tomographic tracer for the selective metabolic imaging of brain tumor and may be used in an appropriate model as a marker for tumor growth rate.",

author = "Nora Volkow and Goldman, {Stephen S.} and Flamm, {Eugene S.} and Humberto Cravioto and Wolf, {Alfred P.} and Brodie, {Jonathan D.}",

year = "1983",

doi = "10.1126/science.6603020",

language = "English (US)",

volume = "221",

pages = "673--675",

journal = "Science",

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T1 - Labeled putrescine as a probe in brain tumors

AU - Volkow, Nora

AU - Goldman, Stephen S.

AU - Flamm, Eugene S.

AU - Cravioto, Humberto

AU - Wolf, Alfred P.

AU - Brodie, Jonathan D.

PY - 1983

Y1 - 1983

N2 - The polyamine metabolism of transplanted N-nitrosomethylurea-derived rat glioma was determined with radiolabeled putrescine used as a marker for malignancy. The uptake of putrescine in vivo was complete within 5 minutes and was specific for tumor tissue. The conversion of putrescine to spermine and other metabolites by the tumor was rapid, in contrast to the case for adjacent normal brain. These results suggest that putrescine labeled with carbon-11 may be used as a positron-emission tomographic tracer for the selective metabolic imaging of brain tumor and may be used in an appropriate model as a marker for tumor growth rate.

AB - The polyamine metabolism of transplanted N-nitrosomethylurea-derived rat glioma was determined with radiolabeled putrescine used as a marker for malignancy. The uptake of putrescine in vivo was complete within 5 minutes and was specific for tumor tissue. The conversion of putrescine to spermine and other metabolites by the tumor was rapid, in contrast to the case for adjacent normal brain. These results suggest that putrescine labeled with carbon-11 may be used as a positron-emission tomographic tracer for the selective metabolic imaging of brain tumor and may be used in an appropriate model as a marker for tumor growth rate.

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DO - 10.1126/science.6603020

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VL - 221

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EP - 675

JO - Science

JF - Science

IS - 4611

ER -

Labeled putrescine as a probe in brain tumors

Abstract

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