L-Arginine in diabetes: clinical and preclinical evidence

Imma Forzano; Roberta Avvisato; Fahimeh Varzideh; Stanislovas S. Jankauskas; Angelo Cioppa; Pasquale Mone; Luigi Salemme; Urna Kansakar; Tullio Tesorio; Valentina Trimarco; Gaetano Santulli

doi:10.1186/s12933-023-01827-2

L-Arginine in diabetes: clinical and preclinical evidence

Imma Forzano, Roberta Avvisato, Fahimeh Varzideh, Stanislovas S. Jankauskas, Angelo Cioppa, Pasquale Mone, Luigi Salemme, Urna Kansakar, Tullio Tesorio, Valentina Trimarco, Gaetano Santulli

Medicine

Research output: Contribution to journal › Review article › peer-review

13 Scopus citations

Abstract

L-Arginine (L-Arg), is a semi-essential amino acid involved in the formation of nitric oxide. The functional relevance of L-Arg in diabetes mellitus has been evaluated both in animal models and in human subjects. In the literature there are several lines of evidence indicating that L-Arg has beneficial effects in diabetes and numerous studies advocate its administration to attenuate glucose intolerance in diabetic patients. Here we present a comprehensive overview of the main studies exploring the effects of L-Arg in diabetes, including preclinical and clinical reports on this topic.

Original language	English (US)
Article number	89
Journal	Cardiovascular Diabetology
Volume	22
Issue number	1
DOIs	https://doi.org/10.1186/s12933-023-01827-2
State	Published - Dec 2023

Keywords

Diabetes mellitus
Endothelial dysfunction
GLP-1
Glucose metabolism
L-Arginine
NO

ASJC Scopus subject areas

Internal Medicine
Endocrinology, Diabetes and Metabolism
Cardiology and Cardiovascular Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1186/s12933-023-01827-2

Cite this

@article{1abafc463ea44f269c72fb6f679aa2bd,

title = "L-Arginine in diabetes: clinical and preclinical evidence",

abstract = "L-Arginine (L-Arg), is a semi-essential amino acid involved in the formation of nitric oxide. The functional relevance of L-Arg in diabetes mellitus has been evaluated both in animal models and in human subjects. In the literature there are several lines of evidence indicating that L-Arg has beneficial effects in diabetes and numerous studies advocate its administration to attenuate glucose intolerance in diabetic patients. Here we present a comprehensive overview of the main studies exploring the effects of L-Arg in diabetes, including preclinical and clinical reports on this topic.",

keywords = "Diabetes mellitus, Endothelial dysfunction, GLP-1, Glucose metabolism, L-Arginine, NO",

author = "Imma Forzano and Roberta Avvisato and Fahimeh Varzideh and Jankauskas, {Stanislovas S.} and Angelo Cioppa and Pasquale Mone and Luigi Salemme and Urna Kansakar and Tullio Tesorio and Valentina Trimarco and Gaetano Santulli",

note = "Publisher Copyright: {\textcopyright} 2023, The Author(s).",

year = "2023",

month = dec,

doi = "10.1186/s12933-023-01827-2",

language = "English (US)",

volume = "22",

journal = "Cardiovascular Diabetology",

issn = "1475-2840",

publisher = "BioMed Central",

number = "1",

}

TY - JOUR

T1 - L-Arginine in diabetes

T2 - clinical and preclinical evidence

AU - Forzano, Imma

AU - Avvisato, Roberta

AU - Varzideh, Fahimeh

AU - Jankauskas, Stanislovas S.

AU - Cioppa, Angelo

AU - Mone, Pasquale

AU - Salemme, Luigi

AU - Kansakar, Urna

AU - Tesorio, Tullio

AU - Trimarco, Valentina

AU - Santulli, Gaetano

PY - 2023/12

Y1 - 2023/12

N2 - L-Arginine (L-Arg), is a semi-essential amino acid involved in the formation of nitric oxide. The functional relevance of L-Arg in diabetes mellitus has been evaluated both in animal models and in human subjects. In the literature there are several lines of evidence indicating that L-Arg has beneficial effects in diabetes and numerous studies advocate its administration to attenuate glucose intolerance in diabetic patients. Here we present a comprehensive overview of the main studies exploring the effects of L-Arg in diabetes, including preclinical and clinical reports on this topic.

AB - L-Arginine (L-Arg), is a semi-essential amino acid involved in the formation of nitric oxide. The functional relevance of L-Arg in diabetes mellitus has been evaluated both in animal models and in human subjects. In the literature there are several lines of evidence indicating that L-Arg has beneficial effects in diabetes and numerous studies advocate its administration to attenuate glucose intolerance in diabetic patients. Here we present a comprehensive overview of the main studies exploring the effects of L-Arg in diabetes, including preclinical and clinical reports on this topic.

KW - Diabetes mellitus

KW - Endothelial dysfunction

KW - GLP-1

KW - Glucose metabolism

KW - L-Arginine

KW - NO

UR - http://www.scopus.com/inward/record.url?scp=85152863981&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85152863981&partnerID=8YFLogxK

U2 - 10.1186/s12933-023-01827-2

DO - 10.1186/s12933-023-01827-2

M3 - Review article

C2 - 37072850

AN - SCOPUS:85152863981

SN - 1475-2840

VL - 22

JO - Cardiovascular Diabetology

JF - Cardiovascular Diabetology

IS - 1

M1 - 89

ER -

L-Arginine in diabetes: clinical and preclinical evidence

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this