L-arginine and covid-19: An update

Ayobami Adebayo; Fahimeh Varzideh; Scott Wilson; Jessica Gambardella; Michael Eacobacci; Stanislovas S. Jankauskas; Kwame Donkor; Urna Kansakar; Valentina Trimarco; Pasquale Mone; Angela Lombardi; Gaetano Santulli

doi:10.3390/nu13113951

L-arginine and covid-19: An update

Ayobami Adebayo, Fahimeh Varzideh, Scott Wilson, Jessica Gambardella, Michael Eacobacci, Stanislovas S. Jankauskas, Kwame Donkor, Urna Kansakar, Valentina Trimarco, Pasquale Mone, Angela Lombardi, Gaetano Santulli

Medicine

Research output: Contribution to journal › Review article › peer-review

42 Scopus citations

Abstract

L-Arginine is involved in many different biological processes and recent reports indicate that it could also play a crucial role in the coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Herein, we present an updated systematic overview of the current evidence on the functional contribution of L-Arginine in COVID-19, describing its actions on endothelial cells and the immune system and discussing its potential as a therapeutic tool, emerged from recent clinical experimentations.

Original language	English (US)
Article number	3951
Journal	Nutrients
Volume	13
Issue number	11
DOIs	https://doi.org/10.3390/nu13113951
State	Published - Nov 2021

Keywords

Antiviral therapies
Arginine
COVID-19
Coronavirus
Cytokine storm
Endothelium
Immune response
Immunity
Inflammation
Nitric oxide
Nitrosylation
Oxidative stress
ROS
SARS-CoV-2
T cells
Viral infections

ASJC Scopus subject areas

Food Science
Nutrition and Dietetics

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10.3390/nu13113951

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title = "L-arginine and covid-19: An update",

abstract = "L-Arginine is involved in many different biological processes and recent reports indicate that it could also play a crucial role in the coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Herein, we present an updated systematic overview of the current evidence on the functional contribution of L-Arginine in COVID-19, describing its actions on endothelial cells and the immune system and discussing its potential as a therapeutic tool, emerged from recent clinical experimentations.",

keywords = "Antiviral therapies, Arginine, COVID-19, Coronavirus, Cytokine storm, Endothelium, Immune response, Immunity, Inflammation, Nitric oxide, Nitrosylation, Oxidative stress, ROS, SARS-CoV-2, T cells, Viral infections",

author = "Ayobami Adebayo and Fahimeh Varzideh and Scott Wilson and Jessica Gambardella and Michael Eacobacci and Jankauskas, {Stanislovas S.} and Kwame Donkor and Urna Kansakar and Valentina Trimarco and Pasquale Mone and Angela Lombardi and Gaetano Santulli",

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AU - Adebayo, Ayobami

AU - Varzideh, Fahimeh

AU - Wilson, Scott

AU - Gambardella, Jessica

AU - Eacobacci, Michael

AU - Jankauskas, Stanislovas S.

AU - Donkor, Kwame

AU - Kansakar, Urna

AU - Trimarco, Valentina

AU - Mone, Pasquale

AU - Lombardi, Angela

AU - Santulli, Gaetano

PY - 2021/11

Y1 - 2021/11

N2 - L-Arginine is involved in many different biological processes and recent reports indicate that it could also play a crucial role in the coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Herein, we present an updated systematic overview of the current evidence on the functional contribution of L-Arginine in COVID-19, describing its actions on endothelial cells and the immune system and discussing its potential as a therapeutic tool, emerged from recent clinical experimentations.

AB - L-Arginine is involved in many different biological processes and recent reports indicate that it could also play a crucial role in the coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Herein, we present an updated systematic overview of the current evidence on the functional contribution of L-Arginine in COVID-19, describing its actions on endothelial cells and the immune system and discussing its potential as a therapeutic tool, emerged from recent clinical experimentations.

KW - Antiviral therapies

KW - Arginine

KW - COVID-19

KW - Coronavirus

KW - Cytokine storm

KW - Endothelium

KW - Immune response

KW - Immunity

KW - Inflammation

KW - Nitric oxide

KW - Nitrosylation

KW - Oxidative stress

KW - ROS

KW - SARS-CoV-2

KW - T cells

KW - Viral infections

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DO - 10.3390/nu13113951

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VL - 13

JO - Nutrients

JF - Nutrients

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ER -

L-arginine and covid-19: An update

Abstract

Keywords

ASJC Scopus subject areas

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