Kv1 channels selectively prevent dendritic hyperexcitability in rat Purkinje cells

Simin Khavandgar, Joy T. Walter, Kristin Sageser, Kamran Khodakhah

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Purkinje cells, the sole output of the cerebellar cortex, encode the timing signals required for motor coordination in their firing rate and activity pattern. Dendrites of Purkinje cells express a high density of P/Q-type voltage-gated calcium channels and fire dendritic calcium spikes. Here we show that dendritic subthreshold Kv1.2 subunit-containing Kv1 potassium channels prevent generation of random spontaneous calcium spikes. With Kv1 channels blocked, dendritic calcium spikes drive bursts of somatic sodium spikes and prevent the cell from faithfully encoding motor timing signals. The selective dendritic function of Kv1 channels in Purkinje cells allows them to effectively suppress dendritic hyperexcitability without hindering the generation of somatic action potentials. Further, we show that Kv1 channels also contribute to dendritic integration of parallel fibre synaptic input. Kv1 channels are often targeted to soma and axon and the data presented support a major dendritic function for these channels.

Original languageEnglish (US)
Pages (from-to)545-557
Number of pages13
JournalJournal of Physiology
Volume569
Issue number2
DOIs
StatePublished - Dec 1 2005

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Calcium Signaling
Purkinje Cells
Shaker Superfamily of Potassium Channels
Cerebellar Cortex
Carisoprodol
Calcium Channels
Dendrites
Action Potentials
Axons
Sodium

ASJC Scopus subject areas

  • Physiology

Cite this

Kv1 channels selectively prevent dendritic hyperexcitability in rat Purkinje cells. / Khavandgar, Simin; Walter, Joy T.; Sageser, Kristin; Khodakhah, Kamran.

In: Journal of Physiology, Vol. 569, No. 2, 01.12.2005, p. 545-557.

Research output: Contribution to journalArticle

Khavandgar, Simin ; Walter, Joy T. ; Sageser, Kristin ; Khodakhah, Kamran. / Kv1 channels selectively prevent dendritic hyperexcitability in rat Purkinje cells. In: Journal of Physiology. 2005 ; Vol. 569, No. 2. pp. 545-557.
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