Abstract
Ku80 facilitates DNA repair and therefore should suppress cancer. However, ku80-/- mice exhibit reduced cancer, although they age prematurely and have a shortened life span. We tested the hypothesis that Ku80 deletion suppresses cancer by enhancing cellular tumor-suppressive responses to inefficiently repaired DNA damage. In support of this hypothesis, Ku80 deletion ameliorated tumor burden in APCMIN mice and increased a p53-mediated DNA damage response, DNA lesions, and chromosomal rearrangements. Thus, contrary to its assumed role as a caretaker tumor suppressor, Ku80 facilitates tumor growth most likely by dampening baseline cellular DNA damage responses.
Original language | English (US) |
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Pages (from-to) | 9497-9502 |
Number of pages | 6 |
Journal | Cancer research |
Volume | 68 |
Issue number | 22 |
DOIs | |
State | Published - Nov 15 2008 |
ASJC Scopus subject areas
- Oncology
- Cancer Research