KLP10A and KLP59C: The dynamic duo of microtubule depolymerization

David J. Sharp, Vito Mennella, Daniel W. Buster

Research output: Contribution to journalReview article

10 Scopus citations

Abstract

Kinesin-13s are important effectors of microtubule depolymerization in cells. In a recent series of studies, we examined the roles played by kinesin-13s throughout the cell cycle in Drosophila. Our findings have revealed remarkable coordination between two family members, KLP10A and KLP59C, in which alterations in the relative targeting of these proteins allows them to participate in markedly different tasks at distinct points in the cell cycle. During mitosis, KLP10A and KLP59C function in parallel by targeting to and depolymerizing the opposite ends of kinetochore-associated microtubules, thereby driving poleward chromatid motility by a Pacman-Flux mechanism. Alternatively, during interphase, both proteins target to the same end of the microtubule but act in series to divide the labor of microtubule depolymerization. KLP10A initiates depolymerization while KLP59C perpetuates depolymerization after its initiation. Below, we detail these findings and examine some of their implications.

Original languageEnglish (US)
Pages (from-to)1482-1485
Number of pages4
JournalCell Cycle
Volume4
Issue number11
DOIs
StatePublished - Nov 2005

Keywords

  • Flux
  • KLP10A
  • KLP59C
  • Kinesin-13
  • Microtubule dynamics
  • Pacman

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

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