KLP10A and KLP59C

the dynamic duo of microtubule depolymerization.

David J. Sharp, Vito Mennella, Daniel W. Buster

Research output: Contribution to journalArticle

Abstract

Kinesin-13s are important effectors of microtubule depolymerization in cells. In a recent series of studies, we examined the roles played by kinesin-13s throughout the cell cycle in Drosophila. Our findings have revealed remarkable coordination between two family members, KLP10A and KLP59C, in which alterations in the relative targeting of these proteins allows them to participate in markedly different tasks at distinct points in the cell cycle. During mitosis, KLP10A and KLP59C function in parallel by targeting to and depolymerizing the opposite ends of kinetochore-associated microtubules, thereby driving poleward chromatid motility by a Pacman-Flux mechanism. Alternatively, during interphase, both proteins target to the same end of the microtubule but act in series to divide the labor of microtubule depolymerization. KLP10A initiates depolymerization while KLP59C perpetuates depolymerization after its initiation. Below, we detail these findings and examine some of their implications.

Original languageEnglish (US)
Pages (from-to)1482-1485
Number of pages4
JournalCell cycle (Georgetown, Tex.)
Volume4
Issue number11
StatePublished - Nov 2005

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Microtubules
Kinesin
Cell Cycle
Kinetochores
Chromatids
Interphase
Protein Transport
Mitosis
Drosophila
Proteins

ASJC Scopus subject areas

  • Medicine(all)

Cite this

KLP10A and KLP59C : the dynamic duo of microtubule depolymerization. / Sharp, David J.; Mennella, Vito; Buster, Daniel W.

In: Cell cycle (Georgetown, Tex.), Vol. 4, No. 11, 11.2005, p. 1482-1485.

Research output: Contribution to journalArticle

Sharp, David J. ; Mennella, Vito ; Buster, Daniel W. / KLP10A and KLP59C : the dynamic duo of microtubule depolymerization. In: Cell cycle (Georgetown, Tex.). 2005 ; Vol. 4, No. 11. pp. 1482-1485.
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