KLF1: When less is more

Deepa Manwani; James J. Bieker

doi:10.1182/blood-2014-05-576967

KLF1: When less is more

Deepa Manwani, James J. Bieker

Pediatrics

Research output: Contribution to journal › Comment/debate › peer-review

6 Scopus citations

Abstract

In this issue of Blood, Liu et al gain an understanding of phenotypic variability in hemoglobinopathies.¹ They find that mutations in Krüppel-like factor-1 (KLF1) are significantly more prevalent in patients with β-thalassemia than previously recognized and correlate with a milder phenotype. This supports the emerging concept that monoallelic KLF1 mutations can play a modulatory role in hemoglobinopathies.

Original language	English (US)
Pages (from-to)	672-673
Number of pages	2
Journal	Blood
Volume	124
Issue number	5
DOIs	https://doi.org/10.1182/blood-2014-05-576967
State	Published - Jul 31 2014

ASJC Scopus subject areas

Biochemistry
Immunology
Hematology
Cell Biology

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title = "KLF1: When less is more",

abstract = "In this issue of Blood, Liu et al gain an understanding of phenotypic variability in hemoglobinopathies.1 They find that mutations in Kr{\"u}ppel-like factor-1 (KLF1) are significantly more prevalent in patients with β-thalassemia than previously recognized and correlate with a milder phenotype. This supports the emerging concept that monoallelic KLF1 mutations can play a modulatory role in hemoglobinopathies.",

author = "Deepa Manwani and Bieker, {James J.}",

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AU - Manwani, Deepa

AU - Bieker, James J.

PY - 2014/7/31

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N2 - In this issue of Blood, Liu et al gain an understanding of phenotypic variability in hemoglobinopathies.1 They find that mutations in Krüppel-like factor-1 (KLF1) are significantly more prevalent in patients with β-thalassemia than previously recognized and correlate with a milder phenotype. This supports the emerging concept that monoallelic KLF1 mutations can play a modulatory role in hemoglobinopathies.

AB - In this issue of Blood, Liu et al gain an understanding of phenotypic variability in hemoglobinopathies.1 They find that mutations in Krüppel-like factor-1 (KLF1) are significantly more prevalent in patients with β-thalassemia than previously recognized and correlate with a milder phenotype. This supports the emerging concept that monoallelic KLF1 mutations can play a modulatory role in hemoglobinopathies.

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DO - 10.1182/blood-2014-05-576967

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KLF1: When less is more

Abstract

ASJC Scopus subject areas

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