KLF1

When less is more

Deepa G. Manwani, James J. Bieker

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

In this issue of Blood, Liu et al gain an understanding of phenotypic variability in hemoglobinopathies.1 They find that mutations in Krüppel-like factor-1 (KLF1) are significantly more prevalent in patients with β-thalassemia than previously recognized and correlate with a milder phenotype. This supports the emerging concept that monoallelic KLF1 mutations can play a modulatory role in hemoglobinopathies.

Original languageEnglish (US)
Pages (from-to)672-673
Number of pages2
JournalBlood
Volume124
Issue number5
DOIs
StatePublished - Jul 31 2014

Fingerprint

Blood
Hemoglobinopathies
Mutation
Thalassemia
Phenotype

ASJC Scopus subject areas

  • Hematology
  • Biochemistry
  • Cell Biology
  • Immunology

Cite this

KLF1 : When less is more. / Manwani, Deepa G.; Bieker, James J.

In: Blood, Vol. 124, No. 5, 31.07.2014, p. 672-673.

Research output: Contribution to journalArticle

Manwani, DG & Bieker, JJ 2014, 'KLF1: When less is more', Blood, vol. 124, no. 5, pp. 672-673. https://doi.org/10.1182/blood-2014-05-576967
Manwani, Deepa G. ; Bieker, James J. / KLF1 : When less is more. In: Blood. 2014 ; Vol. 124, No. 5. pp. 672-673.
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