KLF1: When less is more

Deepa Manwani, James J. Bieker

Research output: Contribution to journalComment/debatepeer-review

6 Scopus citations


In this issue of Blood, Liu et al gain an understanding of phenotypic variability in hemoglobinopathies.1 They find that mutations in Krüppel-like factor-1 (KLF1) are significantly more prevalent in patients with β-thalassemia than previously recognized and correlate with a milder phenotype. This supports the emerging concept that monoallelic KLF1 mutations can play a modulatory role in hemoglobinopathies.

Original languageEnglish (US)
Pages (from-to)672-673
Number of pages2
Issue number5
StatePublished - Jul 31 2014

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology


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