Abstract
unc-104 encodes a novel kinesin paralog that may act as a microtubule-based motor In the nervous system. Neuronal cell lineages and axonogenesis are normal in unc-104 null mutants, but axons have few synaptic vesicles and make only a few small synapses. By contrast, neuron cell bodies have surfeits of similar vesicles tethered together within the cytoplasm. Based on behavioral and cellular phenotypes, we suggest that UNC-104 is a neuron-specific motor used for anterograde translocation of synaptic vesicles along axonal microtubuies. Other membrane-bounded organelles are transported normally.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 837-847 |
| Number of pages | 11 |
| Journal | Cell |
| Volume | 65 |
| Issue number | 5 |
| DOIs | |
| State | Published - May 31 1991 |
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ASJC Scopus subject areas
- Cell Biology
- Molecular Biology
Cite this
Kinesin-related gene unc-104 is required for axonal transport of synaptic vesicles in C. elegans. / Hall, David H.; Hedgecock, Edward M.
In: Cell, Vol. 65, No. 5, 31.05.1991, p. 837-847.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Kinesin-related gene unc-104 is required for axonal transport of synaptic vesicles in C. elegans
AU - Hall, David H.
AU - Hedgecock, Edward M.
PY - 1991/5/31
Y1 - 1991/5/31
N2 - unc-104 encodes a novel kinesin paralog that may act as a microtubule-based motor In the nervous system. Neuronal cell lineages and axonogenesis are normal in unc-104 null mutants, but axons have few synaptic vesicles and make only a few small synapses. By contrast, neuron cell bodies have surfeits of similar vesicles tethered together within the cytoplasm. Based on behavioral and cellular phenotypes, we suggest that UNC-104 is a neuron-specific motor used for anterograde translocation of synaptic vesicles along axonal microtubuies. Other membrane-bounded organelles are transported normally.
AB - unc-104 encodes a novel kinesin paralog that may act as a microtubule-based motor In the nervous system. Neuronal cell lineages and axonogenesis are normal in unc-104 null mutants, but axons have few synaptic vesicles and make only a few small synapses. By contrast, neuron cell bodies have surfeits of similar vesicles tethered together within the cytoplasm. Based on behavioral and cellular phenotypes, we suggest that UNC-104 is a neuron-specific motor used for anterograde translocation of synaptic vesicles along axonal microtubuies. Other membrane-bounded organelles are transported normally.
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UR - http://www.scopus.com/inward/citedby.url?scp=0025844789&partnerID=8YFLogxK
U2 - 10.1016/0092-8674(91)90391-B
DO - 10.1016/0092-8674(91)90391-B
M3 - Article
C2 - 1710172
AN - SCOPUS:0025844789
VL - 65
SP - 837
EP - 847
JO - Cell
JF - Cell
SN - 0092-8674
IS - 5
ER -