Kinesin-related gene unc-104 is required for axonal transport of synaptic vesicles in C. elegans

David H. Hall, Edward M. Hedgecock

Research output: Contribution to journalArticle

394 Citations (Scopus)

Abstract

unc-104 encodes a novel kinesin paralog that may act as a microtubule-based motor In the nervous system. Neuronal cell lineages and axonogenesis are normal in unc-104 null mutants, but axons have few synaptic vesicles and make only a few small synapses. By contrast, neuron cell bodies have surfeits of similar vesicles tethered together within the cytoplasm. Based on behavioral and cellular phenotypes, we suggest that UNC-104 is a neuron-specific motor used for anterograde translocation of synaptic vesicles along axonal microtubuies. Other membrane-bounded organelles are transported normally.

Original languageEnglish (US)
Pages (from-to)837-847
Number of pages11
JournalCell
Volume65
Issue number5
DOIs
StatePublished - May 31 1991

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Kinesin
Transport Vesicles
Axonal Transport
Synaptic Vesicles
Neurons
Genes
Neurology
Motor Neurons
Cell Lineage
Microtubules
Organelles
Synapses
Nervous System
Axons
Cytoplasm
Cells
Membranes
Phenotype
Cell Body

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

Cite this

Kinesin-related gene unc-104 is required for axonal transport of synaptic vesicles in C. elegans. / Hall, David H.; Hedgecock, Edward M.

In: Cell, Vol. 65, No. 5, 31.05.1991, p. 837-847.

Research output: Contribution to journalArticle

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