Abstract
unc-104 encodes a novel kinesin paralog that may act as a microtubule-based motor In the nervous system. Neuronal cell lineages and axonogenesis are normal in unc-104 null mutants, but axons have few synaptic vesicles and make only a few small synapses. By contrast, neuron cell bodies have surfeits of similar vesicles tethered together within the cytoplasm. Based on behavioral and cellular phenotypes, we suggest that UNC-104 is a neuron-specific motor used for anterograde translocation of synaptic vesicles along axonal microtubuies. Other membrane-bounded organelles are transported normally.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 837-847 |
| Number of pages | 11 |
| Journal | Cell |
| Volume | 65 |
| Issue number | 5 |
| DOIs | |
| State | Published - May 31 1991 |
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
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Hall, D. H., & Hedgecock, E. M. (1991). Kinesin-related gene unc-104 is required for axonal transport of synaptic vesicles in C. elegans. Cell, 65(5), 837-847. https://doi.org/10.1016/0092-8674(91)90391-B