Kinesin-related gene unc-104 is required for axonal transport of synaptic vesicles in C. elegans

David H. Hall; Edward M. Hedgecock

doi:10.1016/0092-8674(91)90391-B

Kinesin-related gene unc-104 is required for axonal transport of synaptic vesicles in C. elegans

David H. Hall, Edward M. Hedgecock

Neuroscience

Research output: Contribution to journal › Article › peer-review

406 Scopus citations

Abstract

unc-104 encodes a novel kinesin paralog that may act as a microtubule-based motor In the nervous system. Neuronal cell lineages and axonogenesis are normal in unc-104 null mutants, but axons have few synaptic vesicles and make only a few small synapses. By contrast, neuron cell bodies have surfeits of similar vesicles tethered together within the cytoplasm. Based on behavioral and cellular phenotypes, we suggest that UNC-104 is a neuron-specific motor used for anterograde translocation of synaptic vesicles along axonal microtubuies. Other membrane-bounded organelles are transported normally.

Original language	English (US)
Pages (from-to)	837-847
Number of pages	11
Journal	Cell
Volume	65
Issue number	5
DOIs	https://doi.org/10.1016/0092-8674(91)90391-B
State	Published - May 31 1991

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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@article{93539670f56e460dba2ae13e0d3d3cda,

title = "Kinesin-related gene unc-104 is required for axonal transport of synaptic vesicles in C. elegans",

abstract = "unc-104 encodes a novel kinesin paralog that may act as a microtubule-based motor In the nervous system. Neuronal cell lineages and axonogenesis are normal in unc-104 null mutants, but axons have few synaptic vesicles and make only a few small synapses. By contrast, neuron cell bodies have surfeits of similar vesicles tethered together within the cytoplasm. Based on behavioral and cellular phenotypes, we suggest that UNC-104 is a neuron-specific motor used for anterograde translocation of synaptic vesicles along axonal microtubuies. Other membrane-bounded organelles are transported normally.",

author = "Hall, {David H.} and Hedgecock, {Edward M.}",

note = "Funding Information: We thank D. Riddle, M. Shen, and the Caenorhabditis Genetics Center for providing strains; H. Bhatt for examining the PVP neurons with MAb44; H. Rubin for photographic services; A. Gtsuka and A. Jeyapra-kash for sharing the DNA sequence of uric-104; and P. Meluh, C. Norris, A. Dtsuka, and W. Wadsworth for helpful discussions. This work was supported by NIH grants NS07512 (D. H. H./M. V. L. Bennett) and NS26295 (E. M. H.) and by Hoffmann-LaRoche.",

year = "1991",

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doi = "10.1016/0092-8674(91)90391-B",

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AU - Hall, David H.

AU - Hedgecock, Edward M.

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PY - 1991/5/31

Y1 - 1991/5/31

N2 - unc-104 encodes a novel kinesin paralog that may act as a microtubule-based motor In the nervous system. Neuronal cell lineages and axonogenesis are normal in unc-104 null mutants, but axons have few synaptic vesicles and make only a few small synapses. By contrast, neuron cell bodies have surfeits of similar vesicles tethered together within the cytoplasm. Based on behavioral and cellular phenotypes, we suggest that UNC-104 is a neuron-specific motor used for anterograde translocation of synaptic vesicles along axonal microtubuies. Other membrane-bounded organelles are transported normally.

AB - unc-104 encodes a novel kinesin paralog that may act as a microtubule-based motor In the nervous system. Neuronal cell lineages and axonogenesis are normal in unc-104 null mutants, but axons have few synaptic vesicles and make only a few small synapses. By contrast, neuron cell bodies have surfeits of similar vesicles tethered together within the cytoplasm. Based on behavioral and cellular phenotypes, we suggest that UNC-104 is a neuron-specific motor used for anterograde translocation of synaptic vesicles along axonal microtubuies. Other membrane-bounded organelles are transported normally.

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