Kindling in developing rats: variability of afterdischarge thresholds with age

Solomon L. Moshé, Nansie S. Sharpless, Jerry Kaplan

Research output: Contribution to journalArticle

75 Scopus citations

Abstract

In the kindling model, the occurrence of afterdischarges is necessary for the development of seizures. In this study, the afterdischarge thresholds of the amygdala were determined in rats of different age groups, beginning with 15-day-old suckling rats. Afterdischarges were triggered in 75% of the suckling rats and in all of the rats in the older age groups. The afterdischarge thresholds varied with age, being highest in the suckling group, lowest in the 35-day-old group and intermediate in the older groups. This variability of the thresholds did not correlate with the alterations in the catecholamine levels in the amygdala that occur during maturation. The failure of 25% of suckling rats to develop afterdischarges may explain why some suckling rats do not kindle.

Original languageEnglish (US)
Pages (from-to)190-195
Number of pages6
JournalBrain Research
Volume211
Issue number1
DOIs
Publication statusPublished - Apr 27 1981

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Keywords

  • afterdischarge thresholds
  • catecholamine
  • kindling
  • maturation
  • rats

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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