Abstract
The effects of kindling induced in developing rat pups were re-examined when the rats reached maturity. Eighteen-day-old rats, implanted with bipolar electrodes, were separated into the following 4 groups: the fully kindled group consisted of pups that developed generalized convulsions; the partially kindled group of pups that consistently displayed afterdischarges and occasionally behavioral focal seizures; the afterdischarge group of pups in which the afterdischarge threshold was measured and the non-stimulated group of pups implanted but not stimulated. Subsequently, the electrodes were removed and the rats were allowed to grow. At 65-70 days, the surviving rats and age matched controls were rekindled. The vulnerability to kindled convulsions at maturity, as expressed by the kindling rates, correlated directly with the severity of previous kindled seizures, but did not correlate with the presence of long standing gliotic lesions. These findings suggest that the neural alterations evoked by kindling persist and are not modified by the dynamic changes that occur with growth.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 67-71 |
| Number of pages | 5 |
| Journal | Developmental Brain Research |
| Volume | 4 |
| Issue number | 1 |
| DOIs | |
| State | Published - 1982 |
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Keywords
- adult rats
- afterdischarges
- amygdala
- kindling
- maturation
- seizures
- suckling rats
ASJC Scopus subject areas
- Developmental Biology
- Developmental Neuroscience
Cite this
Kindling in developing rats : Persistence of seizures into adulthood. / Moshe, Solomon L.; Albala, Bruce J.
In: Developmental Brain Research, Vol. 4, No. 1, 1982, p. 67-71.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Kindling in developing rats
T2 - Persistence of seizures into adulthood
AU - Moshe, Solomon L.
AU - Albala, Bruce J.
PY - 1982
Y1 - 1982
N2 - The effects of kindling induced in developing rat pups were re-examined when the rats reached maturity. Eighteen-day-old rats, implanted with bipolar electrodes, were separated into the following 4 groups: the fully kindled group consisted of pups that developed generalized convulsions; the partially kindled group of pups that consistently displayed afterdischarges and occasionally behavioral focal seizures; the afterdischarge group of pups in which the afterdischarge threshold was measured and the non-stimulated group of pups implanted but not stimulated. Subsequently, the electrodes were removed and the rats were allowed to grow. At 65-70 days, the surviving rats and age matched controls were rekindled. The vulnerability to kindled convulsions at maturity, as expressed by the kindling rates, correlated directly with the severity of previous kindled seizures, but did not correlate with the presence of long standing gliotic lesions. These findings suggest that the neural alterations evoked by kindling persist and are not modified by the dynamic changes that occur with growth.
AB - The effects of kindling induced in developing rat pups were re-examined when the rats reached maturity. Eighteen-day-old rats, implanted with bipolar electrodes, were separated into the following 4 groups: the fully kindled group consisted of pups that developed generalized convulsions; the partially kindled group of pups that consistently displayed afterdischarges and occasionally behavioral focal seizures; the afterdischarge group of pups in which the afterdischarge threshold was measured and the non-stimulated group of pups implanted but not stimulated. Subsequently, the electrodes were removed and the rats were allowed to grow. At 65-70 days, the surviving rats and age matched controls were rekindled. The vulnerability to kindled convulsions at maturity, as expressed by the kindling rates, correlated directly with the severity of previous kindled seizures, but did not correlate with the presence of long standing gliotic lesions. These findings suggest that the neural alterations evoked by kindling persist and are not modified by the dynamic changes that occur with growth.
KW - adult rats
KW - afterdischarges
KW - amygdala
KW - kindling
KW - maturation
KW - seizures
KW - suckling rats
UR - http://www.scopus.com/inward/record.url?scp=0019991405&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0019991405&partnerID=8YFLogxK
U2 - 10.1016/0165-3806(82)90097-9
DO - 10.1016/0165-3806(82)90097-9
M3 - Article
VL - 4
SP - 67
EP - 71
JO - Developmental Brain Research
JF - Developmental Brain Research
SN - 0165-3806
IS - 1
ER -