Kidney function and sudden cardiac death in the community

The Atherosclerosis Risk in Communities (ARIC) Study

Takeki Suzuki, Sunil K. Agarwal, Rajat Deo, Nona Sotoodehnia, Morgan E. Grams, Elizabeth Selvin, Hugh Calkins, Wayne Rosamond, Gordon F. Tomaselli, Josef Coresh, Kunihiro Matsushita

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Individuals with chronic kidney disease, particularly those requiring dialysis, are at high risk of sudden cardiac death (SCD). However, comprehensive data for the full spectrum of kidney function and SCD risk in the community are sparse. Furthermore, newly developed equations for estimated glomerular filtration rate (eGFR) and novel filtration markers might add further insight to the role of kidney function in SCD. Methods We investigated the associations of baseline eGFRs using serum creatinine, cystatin C, or both (eGFRcr, eGFRcys, and eGFRcr-cys); cystatin C itself; and β2-microglobulin (B2M) with SCD (205 cases through 2001) among 13,070 black and white ARIC participants at baseline during 1990-1992 using Cox regression models accounting for potential confounders. Results Low eGFR was independently associated with SCD risk: for example, hazard ratio for eGFR <45 versus ≥90 mL/(min 1.73m2) was 3.71 (95% CI 1.74-7.90) with eGFRcr, 5.40 (2.97-9.83) with eGFRcr-cys, and 5.24 (3.01-9.11) with eGFRcys. When eGFRcr and eGFRcys were included together in a single model, the association was only significant for eGFRcys. When three eGFRs, cystatin C, and B2M were divided into quartiles, B2M demonstrated the strongest association with SCD (hazard ratio for fourth quartile vs first quartile 3.48 (2.03-5.96) vs ≤2.7 for the other kidney markers). Conclusions Kidney function was independently and robustly associated with SCD in the community, particularly when cystatin C or B2M was used. These results suggest the potential value of kidney function as a risk factor for SCD and the advantage of novel filtration markers over eGFRcr in this context.

Original languageEnglish (US)
Pages (from-to)1-8
Number of pages8
JournalAmerican Heart Journal
Volume180
DOIs
StatePublished - Oct 1 2016
Externally publishedYes

Fingerprint

Sudden Cardiac Death
Atherosclerosis
Kidney
Cystatin C
Glomerular Filtration Rate
Chronic Renal Insufficiency
Proportional Hazards Models
Dialysis
Creatinine
Serum

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Suzuki, T., Agarwal, S. K., Deo, R., Sotoodehnia, N., Grams, M. E., Selvin, E., ... Matsushita, K. (2016). Kidney function and sudden cardiac death in the community: The Atherosclerosis Risk in Communities (ARIC) Study. American Heart Journal, 180, 1-8. https://doi.org/10.1016/j.ahj.2016.07.004

Kidney function and sudden cardiac death in the community : The Atherosclerosis Risk in Communities (ARIC) Study. / Suzuki, Takeki; Agarwal, Sunil K.; Deo, Rajat; Sotoodehnia, Nona; Grams, Morgan E.; Selvin, Elizabeth; Calkins, Hugh; Rosamond, Wayne; Tomaselli, Gordon F.; Coresh, Josef; Matsushita, Kunihiro.

In: American Heart Journal, Vol. 180, 01.10.2016, p. 1-8.

Research output: Contribution to journalArticle

Suzuki, T, Agarwal, SK, Deo, R, Sotoodehnia, N, Grams, ME, Selvin, E, Calkins, H, Rosamond, W, Tomaselli, GF, Coresh, J & Matsushita, K 2016, 'Kidney function and sudden cardiac death in the community: The Atherosclerosis Risk in Communities (ARIC) Study', American Heart Journal, vol. 180, pp. 1-8. https://doi.org/10.1016/j.ahj.2016.07.004
Suzuki, Takeki ; Agarwal, Sunil K. ; Deo, Rajat ; Sotoodehnia, Nona ; Grams, Morgan E. ; Selvin, Elizabeth ; Calkins, Hugh ; Rosamond, Wayne ; Tomaselli, Gordon F. ; Coresh, Josef ; Matsushita, Kunihiro. / Kidney function and sudden cardiac death in the community : The Atherosclerosis Risk in Communities (ARIC) Study. In: American Heart Journal. 2016 ; Vol. 180. pp. 1-8.
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abstract = "Individuals with chronic kidney disease, particularly those requiring dialysis, are at high risk of sudden cardiac death (SCD). However, comprehensive data for the full spectrum of kidney function and SCD risk in the community are sparse. Furthermore, newly developed equations for estimated glomerular filtration rate (eGFR) and novel filtration markers might add further insight to the role of kidney function in SCD. Methods We investigated the associations of baseline eGFRs using serum creatinine, cystatin C, or both (eGFRcr, eGFRcys, and eGFRcr-cys); cystatin C itself; and β2-microglobulin (B2M) with SCD (205 cases through 2001) among 13,070 black and white ARIC participants at baseline during 1990-1992 using Cox regression models accounting for potential confounders. Results Low eGFR was independently associated with SCD risk: for example, hazard ratio for eGFR <45 versus ≥90 mL/(min 1.73m2) was 3.71 (95{\%} CI 1.74-7.90) with eGFRcr, 5.40 (2.97-9.83) with eGFRcr-cys, and 5.24 (3.01-9.11) with eGFRcys. When eGFRcr and eGFRcys were included together in a single model, the association was only significant for eGFRcys. When three eGFRs, cystatin C, and B2M were divided into quartiles, B2M demonstrated the strongest association with SCD (hazard ratio for fourth quartile vs first quartile 3.48 (2.03-5.96) vs ≤2.7 for the other kidney markers). Conclusions Kidney function was independently and robustly associated with SCD in the community, particularly when cystatin C or B2M was used. These results suggest the potential value of kidney function as a risk factor for SCD and the advantage of novel filtration markers over eGFRcr in this context.",
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