Key roles of autophagy in regulating T-cell function

Yair M. Botbol, Ignacio Guerrero-Ros, Fernando Macian-Juan

Research output: Contribution to journalReview article

23 Scopus citations

Abstract

In the past 10 years, autophagy has emerged as a crucial regulator of T-cell homeostasis, activation, and differentiation. Through the ability to adjust the cell's proteome in response to different stimuli, different forms of autophagy have been shown to control T-cell homeostasis and survival. Autophagic processes can also determine the magnitude of the T-cell response to TCR engagement, by regulating the cellular levels of specific signaling intermediates and modulating the metabolic output in activated T cells. In this review we will examine the mechanisms that control autophagy activity in T cells, such as ROS signaling and signaling through common gamma-chain cytokine receptors, and the different aspect of T-cell biology, including T-cell survival, effector cell function, and generation of memory, which can be regulated by autophagy.

Original languageEnglish (US)
Pages (from-to)1326-1334
Number of pages9
JournalEuropean Journal of Immunology
Volume46
Issue number6
DOIs
StatePublished - Jun 1 2016

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Keywords

  • Autophagy
  • Chaperone-mediated autophagy
  • Macroautophagy
  • Metabolism
  • T cell

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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