TY - JOUR
T1 - Key roles of autophagy in regulating T-cell function
AU - Botbol, Yair
AU - Guerrero-Ros, Ignacio
AU - Macian, Fernando
N1 - Publisher Copyright:
© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
PY - 2016/6/1
Y1 - 2016/6/1
N2 - In the past 10 years, autophagy has emerged as a crucial regulator of T-cell homeostasis, activation, and differentiation. Through the ability to adjust the cell's proteome in response to different stimuli, different forms of autophagy have been shown to control T-cell homeostasis and survival. Autophagic processes can also determine the magnitude of the T-cell response to TCR engagement, by regulating the cellular levels of specific signaling intermediates and modulating the metabolic output in activated T cells. In this review we will examine the mechanisms that control autophagy activity in T cells, such as ROS signaling and signaling through common gamma-chain cytokine receptors, and the different aspect of T-cell biology, including T-cell survival, effector cell function, and generation of memory, which can be regulated by autophagy.
AB - In the past 10 years, autophagy has emerged as a crucial regulator of T-cell homeostasis, activation, and differentiation. Through the ability to adjust the cell's proteome in response to different stimuli, different forms of autophagy have been shown to control T-cell homeostasis and survival. Autophagic processes can also determine the magnitude of the T-cell response to TCR engagement, by regulating the cellular levels of specific signaling intermediates and modulating the metabolic output in activated T cells. In this review we will examine the mechanisms that control autophagy activity in T cells, such as ROS signaling and signaling through common gamma-chain cytokine receptors, and the different aspect of T-cell biology, including T-cell survival, effector cell function, and generation of memory, which can be regulated by autophagy.
KW - Autophagy
KW - Chaperone-mediated autophagy
KW - Macroautophagy
KW - Metabolism
KW - T cell
UR - http://www.scopus.com/inward/record.url?scp=84973663352&partnerID=8YFLogxK
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U2 - 10.1002/eji.201545955
DO - 10.1002/eji.201545955
M3 - Review article
C2 - 27151577
AN - SCOPUS:84973663352
SN - 0014-2980
VL - 46
SP - 1326
EP - 1334
JO - European Journal of Immunology
JF - European Journal of Immunology
IS - 6
ER -