TY - JOUR
T1 - Key issues in trial design for ventricular assist devices
T2 - A position statement of the Heart Failure Society of America
AU - Konstam, Marvin A.
AU - Lindenfeld, Joann
AU - Pina, Ileana L.
AU - Packer, Milton
AU - Lazar, Ronald M.
AU - Warner Stevenson, Lynne
PY - 2004/4
Y1 - 2004/4
N2 - A wide array of novel medical devices on the horizon offers promise of substantial clinical benefit to patients with heart failure, including those presently considered to be "end-stage." VADs are an established tool for allowing critically ill patients to undergo cardiac transplant. We have witnessed the first definitive demonstration of survival benefit from VADs as destination devices. Novel advances in VAD design hold the potential for expanding the indication to broader populations and offering improved survival, H-QOL, and device reliability, and/or reduced device-related morbidity. The challenge will be to design clinical trials that will expedite advances in the field, while assuring the safety and efficacy of new devices. Such designs will facilitate the application of new devices as bridges to transplant, as destination therapy, and as instruments for improvement in underlying cardiac pathology.
AB - A wide array of novel medical devices on the horizon offers promise of substantial clinical benefit to patients with heart failure, including those presently considered to be "end-stage." VADs are an established tool for allowing critically ill patients to undergo cardiac transplant. We have witnessed the first definitive demonstration of survival benefit from VADs as destination devices. Novel advances in VAD design hold the potential for expanding the indication to broader populations and offering improved survival, H-QOL, and device reliability, and/or reduced device-related morbidity. The challenge will be to design clinical trials that will expedite advances in the field, while assuring the safety and efficacy of new devices. Such designs will facilitate the application of new devices as bridges to transplant, as destination therapy, and as instruments for improvement in underlying cardiac pathology.
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U2 - 10.1016/j.cardfail.2004.02.009
DO - 10.1016/j.cardfail.2004.02.009
M3 - Article
C2 - 15101019
AN - SCOPUS:3042747124
SN - 1071-9164
VL - 10
SP - 91
EP - 100
JO - Journal of Cardiac Failure
JF - Journal of Cardiac Failure
IS - 2
ER -