K:Cl cotransport activity is inhibited by HCO3- in knockout mouse red cells expressing human HbC

José R. Romero, Sandra M. Suzuka, Grace V. Romero-González, Ronald L. Nagel, Mary E. Fabry

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Abstract

K:Cl cotransport (KCl) was examined in transgenic mice expressing exclusively human hemoglobin C. In contrast to previous studies in early transgenic mice expressing human α and βs and residual mouse globins, we found significant volume and pH stimulation and sensitivity to NO3-. Exposure to physiological levels of HCO3- also blocked a significant fraction of KCl cotransport

Original languageEnglish (US)
Pages (from-to)69-70
Number of pages2
JournalBlood Cells, Molecules, and Diseases
Volume27
Issue number1
DOIs
StatePublished - Jan 1 2001

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