TY - JOUR
T1 - Kaposi Sarcoma of the Larynx
T2 - A Systematic Review
AU - Barron, Kendyl
AU - Omiunu, Ariel
AU - Celidonio, Joseph
AU - Cruz-Mullane, Alexandra
AU - Din-Lovinescu, Corina
AU - Chemas-Velez, Maria Manuela
AU - Baredes, Soly
AU - Eloy, Jean Anderson
AU - Fang, Christina H.
N1 - Publisher Copyright:
© 2022 American Academy of Otolaryngology–Head and Neck Surgery Foundation.
PY - 2023/3
Y1 - 2023/3
N2 - Objective: Kaposi sarcoma (KS) of the larynx is a rare disease with few cases reported in the literature. This study aims to provide a comprehensive review of laryngeal KS, including patient characteristics, treatment, and clinical outcomes. Data Sources: PubMed, CINAHL, SCOPUS, and Cochrane Library. Review Methods: A systematic review of the published English literature was conducted. An electronic search and bibliographic examination of articles pertaining to laryngeal KS were performed. Demographic data, tumor site, treatment strategies, follow-up, and outcome were analyzed. Results: A total 77 cases from 50 articles were included in the review. The mean age was 47.6 years (range, 8-81). There was an 8.6:1 male:female ratio. The most common presenting symptoms were dyspnea (n = 35) and hoarseness (n = 25). Laryngeal KS arose most frequently in the supraglottic region (n = 16). Chemotherapy alone (n = 27) was the most common treatment modality in patients with AIDS-associated KS, and surgical excision alone (n = 7) was most common in patients with other subtypes of KS (eg, classic, transplant associated). Average follow-up was 20.4 months (range, 0.75-120). Most patients with AIDS-associated KS died of other causes (n = 25), but most patients with other subtypes of KS were alive with no evidence of disease at follow-up (n = 13). Conclusion: This review contains the largest pool of laryngeal KS cases to date. Long-term outcomes were generally unfavorable, often due to advanced HIV disease at the time of diagnosis.
AB - Objective: Kaposi sarcoma (KS) of the larynx is a rare disease with few cases reported in the literature. This study aims to provide a comprehensive review of laryngeal KS, including patient characteristics, treatment, and clinical outcomes. Data Sources: PubMed, CINAHL, SCOPUS, and Cochrane Library. Review Methods: A systematic review of the published English literature was conducted. An electronic search and bibliographic examination of articles pertaining to laryngeal KS were performed. Demographic data, tumor site, treatment strategies, follow-up, and outcome were analyzed. Results: A total 77 cases from 50 articles were included in the review. The mean age was 47.6 years (range, 8-81). There was an 8.6:1 male:female ratio. The most common presenting symptoms were dyspnea (n = 35) and hoarseness (n = 25). Laryngeal KS arose most frequently in the supraglottic region (n = 16). Chemotherapy alone (n = 27) was the most common treatment modality in patients with AIDS-associated KS, and surgical excision alone (n = 7) was most common in patients with other subtypes of KS (eg, classic, transplant associated). Average follow-up was 20.4 months (range, 0.75-120). Most patients with AIDS-associated KS died of other causes (n = 25), but most patients with other subtypes of KS were alive with no evidence of disease at follow-up (n = 13). Conclusion: This review contains the largest pool of laryngeal KS cases to date. Long-term outcomes were generally unfavorable, often due to advanced HIV disease at the time of diagnosis.
KW - AIDS
KW - HIV
KW - Kaposi sarcoma
KW - chemotherapy
KW - human herpesvirus 8
KW - larynx
KW - radiotherapy
KW - surgical management
KW - systematic review
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U2 - 10.1177/01945998221105059
DO - 10.1177/01945998221105059
M3 - Review article
C2 - 35671149
AN - SCOPUS:85131567189
SN - 0194-5998
VL - 168
SP - 269
EP - 281
JO - Otolaryngology - Head and Neck Surgery (United States)
JF - Otolaryngology - Head and Neck Surgery (United States)
IS - 3
ER -