K-Ras, Intestinal homeostasis and colon cancer

Sanjay Goel, Jie Huang, Lidija Klampfer

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Activating Ras mutations, present in about 20% of human cancers, compromise the GTPase activity of Ras and therefore trigger accumulation of Ras in the GTP-bound state. Among the three family members, K-Ras, H-Ras and N-Ras, K-Ras is the most frequently mutated gene, with 30-50% of colon cancer patients harboring activating K-Ras mutations. Oncogenic mutations of K-Ras have been found at codons 12, 13, 61 and 146. Activation of Ras triggers constitutive activation of signaling pathways, including the MAPK and AKT pathways, which allows tumor cells to proliferate in the absence of growth factors and increases their survival. In addition, activated Ras triggers inflammation and thus promotes tumor progression in a cell non-autonomous manner. The presence of K-Ras mutations not only has prognostic value, but it also predicts the responsiveness of colon cancer patients to inhibitors of EGFR signaling.

Original languageEnglish (US)
Pages (from-to)73-81
Number of pages9
JournalCurrent Clinical Pharmacology
Volume10
Issue number1
DOIs
StatePublished - Jan 1 2015

Keywords

  • Colon cancer
  • EGFR inhibitors
  • Inflammation
  • Ras

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology (medical)

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