K: Cl cotransport activity is inhibited by HCO3- in knockout mouse red cells expressing human HbC

José R. Romero, Sandra M. Suzuka, Grace V. Romero-González, Ronald L. Nagel, Mary E. Fabry

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

K:Cl cotransport (KCl) was examined in transgenic mice expressing exclusively human hemoglobin C. In contrast to previous studies in early transgenic mice expressing human α and βs and residual mouse globins, we found significant volume and pH stimulation and sensitivity to NO3-. Exposure to physiological levels of HCO3- also blocked a significant fraction of KCl cotransport

Original languageEnglish (US)
Pages (from-to)69-70
Number of pages2
JournalBlood Cells, Molecules, and Diseases
Volume27
Issue number1
DOIs
StatePublished - 2001

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Knockout Mice
Transgenic Mice
Hemoglobin C
Globins

ASJC Scopus subject areas

  • Molecular Biology
  • Molecular Medicine
  • Hematology

Cite this

K : Cl cotransport activity is inhibited by HCO3- in knockout mouse red cells expressing human HbC. / Romero, José R.; Suzuka, Sandra M.; Romero-González, Grace V.; Nagel, Ronald L.; Fabry, Mary E.

In: Blood Cells, Molecules, and Diseases, Vol. 27, No. 1, 2001, p. 69-70.

Research output: Contribution to journalArticle

Romero, José R. ; Suzuka, Sandra M. ; Romero-González, Grace V. ; Nagel, Ronald L. ; Fabry, Mary E. / K : Cl cotransport activity is inhibited by HCO3- in knockout mouse red cells expressing human HbC. In: Blood Cells, Molecules, and Diseases. 2001 ; Vol. 27, No. 1. pp. 69-70.
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