K:Cl cotransport activity is inhibited by HCO3- in knockout mouse red cells expressing human HbC

José R. Romero; Sandra M. Suzuka; Grace V. Romero-González; Ronald L. Nagel; Mary E. Fabry

doi:10.1006/bcmd.2000.0363

K:Cl cotransport activity is inhibited by HCO₃^- in knockout mouse red cells expressing human HbC

José R. Romero, Sandra M. Suzuka, Grace V. Romero-González, Ronald L. Nagel, Mary E. Fabry

Medicine

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

K:Cl cotransport (KCl) was examined in transgenic mice expressing exclusively human hemoglobin C. In contrast to previous studies in early transgenic mice expressing human α and β^s and residual mouse globins, we found significant volume and pH stimulation and sensitivity to NO₃^-. Exposure to physiological levels of HCO₃^- also blocked a significant fraction of KCl cotransport

Original language	English (US)
Pages (from-to)	69-70
Number of pages	2
Journal	Blood Cells, Molecules, and Diseases
Volume	27
Issue number	1
DOIs	https://doi.org/10.1006/bcmd.2000.0363
State	Published - 2001

ASJC Scopus subject areas

Molecular Medicine
Molecular Biology
Hematology
Cell Biology

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title = "K:Cl cotransport activity is inhibited by HCO3- in knockout mouse red cells expressing human HbC",

abstract = "K:Cl cotransport (KCl) was examined in transgenic mice expressing exclusively human hemoglobin C. In contrast to previous studies in early transgenic mice expressing human α and βs and residual mouse globins, we found significant volume and pH stimulation and sensitivity to NO3-. Exposure to physiological levels of HCO3- also blocked a significant fraction of KCl cotransport",

author = "Romero, {Jos{\'e} R.} and Suzuka, {Sandra M.} and Romero-Gonz{\'a}lez, {Grace V.} and Nagel, {Ronald L.} and Fabry, {Mary E.}",

year = "2001",

doi = "10.1006/bcmd.2000.0363",

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T1 - K:Cl cotransport activity is inhibited by HCO3- in knockout mouse red cells expressing human HbC

AU - Romero, José R.

AU - Suzuka, Sandra M.

AU - Romero-González, Grace V.

AU - Nagel, Ronald L.

AU - Fabry, Mary E.

PY - 2001

Y1 - 2001

N2 - K:Cl cotransport (KCl) was examined in transgenic mice expressing exclusively human hemoglobin C. In contrast to previous studies in early transgenic mice expressing human α and βs and residual mouse globins, we found significant volume and pH stimulation and sensitivity to NO3-. Exposure to physiological levels of HCO3- also blocked a significant fraction of KCl cotransport

AB - K:Cl cotransport (KCl) was examined in transgenic mice expressing exclusively human hemoglobin C. In contrast to previous studies in early transgenic mice expressing human α and βs and residual mouse globins, we found significant volume and pH stimulation and sensitivity to NO3-. Exposure to physiological levels of HCO3- also blocked a significant fraction of KCl cotransport

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DO - 10.1006/bcmd.2000.0363

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AN - SCOPUS:0035049975

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JF - Blood Cells, Molecules, and Diseases

IS - 1

ER -

K:Cl cotransport activity is inhibited by HCO₃^- in knockout mouse red cells expressing human HbC

Abstract

ASJC Scopus subject areas

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