Joint composite-rotation adiabatic-sweep isotope filtration

Elizabeth R. Valentine, Fabien Ferrage, Francesca Massi, David Cowburn, Arthur G. Palmer

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Joint composite-rotation adiabatic-sweep isotope filters are derived by combining the composite-rotation [Stuart AC et al. (1999) J Am Chem Soc 121: 5346-5347] and adiabatic-sweep [Zwahlen C et al. (1997) J Am Chem Soc 119:6711-6721; Kup̂e E, Freeman R (1997) J Magn Reson 127:36-48] approaches. The joint isotope filters have improved broadband filtration performance, even for extreme values of the one-bond 1H-13C scalar coupling constants in proteins and RNA molecules. An average Hamiltonian analysis is used to describe evolution of the heteronuclear scalar coupling interaction during the adiabatic sweeps within the isotope filter sequences. The new isotope filter elements permit improved selective detection of NMR resonance signals originating from 1H spins attached to an unlabeled natural abundance component of a complex in which the other components are labeled with 13C and 15N isotopes.

Original languageEnglish (US)
Pages (from-to)11-22
Number of pages12
JournalJournal of Biomolecular NMR
Volume38
Issue number1
DOIs
StatePublished - May 2007

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Isotopes
Joints
Composite materials
Hamiltonians
Nuclear magnetic resonance
RNA
Molecules
Proteins

Keywords

  • Composite pulse
  • J-filter
  • NOESY
  • Structure determination
  • Vts SAM domain

ASJC Scopus subject areas

  • Spectroscopy
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry

Cite this

Joint composite-rotation adiabatic-sweep isotope filtration. / Valentine, Elizabeth R.; Ferrage, Fabien; Massi, Francesca; Cowburn, David; Palmer, Arthur G.

In: Journal of Biomolecular NMR, Vol. 38, No. 1, 05.2007, p. 11-22.

Research output: Contribution to journalArticle

Valentine, Elizabeth R. ; Ferrage, Fabien ; Massi, Francesca ; Cowburn, David ; Palmer, Arthur G. / Joint composite-rotation adiabatic-sweep isotope filtration. In: Journal of Biomolecular NMR. 2007 ; Vol. 38, No. 1. pp. 11-22.
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