JNK regulation of hepatic manifestations of the metabolic syndrome

Mark J. Czaja

Research output: Contribution to journalReview article

69 Scopus citations

Abstract

Nonalcoholic fatty liver disease (NAFLD) is now recognized as both an important component of the metabolic syndrome and the most prevalent liver disease in the United States. Although the mechanisms for development of steatosis and chronic liver injury in NAFLD remain unclear, recent investigations have indicated that overactivation of c-Jun N-terminal kinase (JNK) is crucial to this process. These findings, together with evidence for the involvement of JNK signaling in other manifestations of the metabolic syndrome such as obesity and insulin resistance, have suggested that JNK could be a novel therapeutic target in this disorder. This review details findings that JNK mediates lipid accumulation and cell injury in fatty liver disease and discusses the possible cellular mechanisms of JNK actions.

Original languageEnglish (US)
Pages (from-to)707-713
Number of pages7
JournalTrends in Endocrinology and Metabolism
Volume21
Issue number12
DOIs
StatePublished - Dec 2010

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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