Jewish and Middle Eastern non-Jewish populations share a common pool of Y-chromosome biallelic haplotypes

M. F. Hammer, A. J. Redd, E. T. Wood, M. R. Bonner, H. Jarjanazi, T. Karafet, S. Santachiara-Benerecetti, A. Oppenheim, M. A. Jobling, T. Jenkins, Harry Ostrer, B. Bonné-Tamir

Research output: Contribution to journalArticle

194 Citations (Scopus)

Abstract

Haplotypes constructed from Y-chromosome markers were used to trace the paternal origins of the Jewish Diaspora. A set of 18 biallelic polymorphisms was genotyped in 1,371 males from 29 populations, including 7 Jewish (Ashkenazi, Roman, North African, Kurdish, Near Eastern, Yemenite, and Ethiopian) and 16 non-Jewish groups from similar geographic locations. The Jewish populations were characterized by a diverse set of 13 haplotypes that were also present in non-Jewish populations from Africa, Asia, and Europe. A series of analyses was performed to address whether modern Jewish Y- chromosome diversity derives mainly from a common Middle Eastern source population or from admixture with neighboring non-Jewish populations during and after the Diaspora. Despite their long-term residence in different countries and isolation from one another, most Jewish populations were not significantly different from one another at the genetic level. Admixture estimates suggested low levels of European Y-chromosome gene flow into Ashkenazi and Roman Jewish communities. A multidimensional scaling plot placed six of the seven Jewish populations in a relatively tight cluster that was interspersed with Middle Eastern non-Jewish populations, including Palestinians and Syrians. Pairwise differentiation tests further indicated that these Jewish and Middle Eastern non-Jewish populations were not statistically different. The results support the hypothesis that the paternal gene pools of Jewish communities from Europe, North Africa, and the Middle East descended from a common Middle Eastern ancestral population, and suggest that most Jewish communities have remained relatively isolated from neighboring non-Jewish communities during and after the Diaspora.

Original languageEnglish (US)
Pages (from-to)6769-6774
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume97
Issue number12
DOIs
StatePublished - Jun 6 2000
Externally publishedYes

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Y Chromosome
Haplotypes
Population
Y-Linked Genes
Gene Pool
Northern Africa
Geographic Locations
Middle East
Gene Flow
Genetic Markers

ASJC Scopus subject areas

  • Genetics
  • General

Cite this

Jewish and Middle Eastern non-Jewish populations share a common pool of Y-chromosome biallelic haplotypes. / Hammer, M. F.; Redd, A. J.; Wood, E. T.; Bonner, M. R.; Jarjanazi, H.; Karafet, T.; Santachiara-Benerecetti, S.; Oppenheim, A.; Jobling, M. A.; Jenkins, T.; Ostrer, Harry; Bonné-Tamir, B.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, No. 12, 06.06.2000, p. 6769-6774.

Research output: Contribution to journalArticle

Hammer, MF, Redd, AJ, Wood, ET, Bonner, MR, Jarjanazi, H, Karafet, T, Santachiara-Benerecetti, S, Oppenheim, A, Jobling, MA, Jenkins, T, Ostrer, H & Bonné-Tamir, B 2000, 'Jewish and Middle Eastern non-Jewish populations share a common pool of Y-chromosome biallelic haplotypes', Proceedings of the National Academy of Sciences of the United States of America, vol. 97, no. 12, pp. 6769-6774. https://doi.org/10.1073/pnas.100115997
Hammer, M. F. ; Redd, A. J. ; Wood, E. T. ; Bonner, M. R. ; Jarjanazi, H. ; Karafet, T. ; Santachiara-Benerecetti, S. ; Oppenheim, A. ; Jobling, M. A. ; Jenkins, T. ; Ostrer, Harry ; Bonné-Tamir, B. / Jewish and Middle Eastern non-Jewish populations share a common pool of Y-chromosome biallelic haplotypes. In: Proceedings of the National Academy of Sciences of the United States of America. 2000 ; Vol. 97, No. 12. pp. 6769-6774.
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AU - Jarjanazi, H.

AU - Karafet, T.

AU - Santachiara-Benerecetti, S.

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AU - Jobling, M. A.

AU - Jenkins, T.

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