Japanese Encephalitis Virus infection induces IL-18 and IL-1β in microglia and astrocytes: Correlation with in vitro cytokine responsiveness of glial cells and subsequent neuronal death

Sulagna Das, Manoj Kumar Mishra, Joydeep Ghosh, Anirban Basu

Research output: Contribution to journalArticle

60 Scopus citations

Abstract

IL-1β and IL-18 are members of the IL-1 family of ligands, and their receptors are members of the IL-1 receptor family. Although several biological properties overlap for these cytokines, differences exist. In order to assess functional importance of these two cytokines in viral encephalitis, we have exploited an experimental model of Japanese Encephalitis (JE) and subsequent in vitro cell culture system. We report for the first time that in Japanese Encephalitis, microglia and astrocytes both produce IL-18 and IL-1β. In vitro, these two cytokines differentially activate microglia and astrocyte, and also alter the by stander neuronal survival following treatment with these two cytokines.

Original languageEnglish (US)
Pages (from-to)60-72
Number of pages13
JournalJournal of Neuroimmunology
Volume195
Issue number1-2
DOIs
StatePublished - Mar 1 2008
Externally publishedYes

Keywords

  • Astrocytes
  • IL-18
  • IL-1β
  • Japanese Encephalitis Virus
  • Microglia
  • Neuron

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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