Japanese encephalitis virus-infected macrophages induce neuronal death

Arshed Nazmi, Kallol Dutta, Sulagna Das, Anirban Basu

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Inflammation in the central nervous system (CNS) in Japanese encephalitis (JE) is shown to be the result of microglial activation that leads to the release of various proinflammatory mediators. Peripheral macrophages have been reported to infiltrate into the CNS in JE, though their contribution to the inflammatory process is yet to be elucidated. In this study, using an in vitro macrophage model, we have shown that upon JE virus infection, these cells secrete various soluble factors which may significantly add to the existing inflammatory milieu and lead to apoptotic or necrotic death of neurons. However, it is difficult to quantify the extent of involvement of either the microglia or infiltrating macrophages in the inflammatory processes.

Original languageEnglish (US)
Pages (from-to)420-433
Number of pages14
JournalJournal of Neuroimmune Pharmacology
Volume6
Issue number3
DOIs
StatePublished - Sep 1 2011
Externally publishedYes

Keywords

  • Apoptosis
  • Cortical neurons
  • Japanese encephalitis virus
  • Primary macrophages

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Immunology and Allergy
  • Immunology
  • Pharmacology

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