Isolated hepatitis B core antibody is associated with HIV and ongoing but not resolved hepatitis C virus infection in a cohort of US women

Audrey L. French, Eva Operskalski, Marion Peters, Howard Strickler, Phyllis C. Tien, Gerald B. Sharp, Marshall J. Glesby, Mary Young, Michael Augenbraun, Eric Seaberg, Andrea Kovacs

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

To characterize predictors of isolated hepatitis B core antibody (anti-HBc) among human immunodeficiency virus (HIV)-infected and HIV-uninfected women, we compared 702 women with anti-HBc and hepatitis B surface antibody (anti-HBs) with 490 women with isolated anti-HBc (1.8% of whom had detectable hepatitis B virus [HBV] DNA). Factors independently associated with isolated anti-HBc without viremia were detectable hepatitis C virus (HCV) RNA, HIV positivity, history of injection drug use, >10 lifetime sex partners, and HIV RNA level >100,000 copies/mL. Anti-HBs levels were lower among anti-HCV-positive women. Isolated anti-HBc was rarely explained by occult HBV in this cohort but may be explained by the influence of viral coinfections on anti-HBs level or durability.

Original languageEnglish (US)
Pages (from-to)1437-1442
Number of pages6
JournalJournal of Infectious Diseases
Volume195
Issue number10
DOIs
StatePublished - May 15 2007

Fingerprint

Hepatitis B Antibodies
Virus Diseases
Hepacivirus
HIV
Hepatitis B virus
RNA
Viremia
Coinfection
Injections
DNA
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Isolated hepatitis B core antibody is associated with HIV and ongoing but not resolved hepatitis C virus infection in a cohort of US women. / French, Audrey L.; Operskalski, Eva; Peters, Marion; Strickler, Howard; Tien, Phyllis C.; Sharp, Gerald B.; Glesby, Marshall J.; Young, Mary; Augenbraun, Michael; Seaberg, Eric; Kovacs, Andrea.

In: Journal of Infectious Diseases, Vol. 195, No. 10, 15.05.2007, p. 1437-1442.

Research output: Contribution to journalArticle

French, AL, Operskalski, E, Peters, M, Strickler, H, Tien, PC, Sharp, GB, Glesby, MJ, Young, M, Augenbraun, M, Seaberg, E & Kovacs, A 2007, 'Isolated hepatitis B core antibody is associated with HIV and ongoing but not resolved hepatitis C virus infection in a cohort of US women', Journal of Infectious Diseases, vol. 195, no. 10, pp. 1437-1442. https://doi.org/10.1086/515578
French, Audrey L. ; Operskalski, Eva ; Peters, Marion ; Strickler, Howard ; Tien, Phyllis C. ; Sharp, Gerald B. ; Glesby, Marshall J. ; Young, Mary ; Augenbraun, Michael ; Seaberg, Eric ; Kovacs, Andrea. / Isolated hepatitis B core antibody is associated with HIV and ongoing but not resolved hepatitis C virus infection in a cohort of US women. In: Journal of Infectious Diseases. 2007 ; Vol. 195, No. 10. pp. 1437-1442.
@article{523e295535df49138b8df192e9c3d5e1,
title = "Isolated hepatitis B core antibody is associated with HIV and ongoing but not resolved hepatitis C virus infection in a cohort of US women",
abstract = "To characterize predictors of isolated hepatitis B core antibody (anti-HBc) among human immunodeficiency virus (HIV)-infected and HIV-uninfected women, we compared 702 women with anti-HBc and hepatitis B surface antibody (anti-HBs) with 490 women with isolated anti-HBc (1.8{\%} of whom had detectable hepatitis B virus [HBV] DNA). Factors independently associated with isolated anti-HBc without viremia were detectable hepatitis C virus (HCV) RNA, HIV positivity, history of injection drug use, >10 lifetime sex partners, and HIV RNA level >100,000 copies/mL. Anti-HBs levels were lower among anti-HCV-positive women. Isolated anti-HBc was rarely explained by occult HBV in this cohort but may be explained by the influence of viral coinfections on anti-HBs level or durability.",
author = "French, {Audrey L.} and Eva Operskalski and Marion Peters and Howard Strickler and Tien, {Phyllis C.} and Sharp, {Gerald B.} and Glesby, {Marshall J.} and Mary Young and Michael Augenbraun and Eric Seaberg and Andrea Kovacs",
year = "2007",
month = "5",
day = "15",
doi = "10.1086/515578",
language = "English (US)",
volume = "195",
pages = "1437--1442",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "10",

}

TY - JOUR

T1 - Isolated hepatitis B core antibody is associated with HIV and ongoing but not resolved hepatitis C virus infection in a cohort of US women

AU - French, Audrey L.

AU - Operskalski, Eva

AU - Peters, Marion

AU - Strickler, Howard

AU - Tien, Phyllis C.

AU - Sharp, Gerald B.

AU - Glesby, Marshall J.

AU - Young, Mary

AU - Augenbraun, Michael

AU - Seaberg, Eric

AU - Kovacs, Andrea

PY - 2007/5/15

Y1 - 2007/5/15

N2 - To characterize predictors of isolated hepatitis B core antibody (anti-HBc) among human immunodeficiency virus (HIV)-infected and HIV-uninfected women, we compared 702 women with anti-HBc and hepatitis B surface antibody (anti-HBs) with 490 women with isolated anti-HBc (1.8% of whom had detectable hepatitis B virus [HBV] DNA). Factors independently associated with isolated anti-HBc without viremia were detectable hepatitis C virus (HCV) RNA, HIV positivity, history of injection drug use, >10 lifetime sex partners, and HIV RNA level >100,000 copies/mL. Anti-HBs levels were lower among anti-HCV-positive women. Isolated anti-HBc was rarely explained by occult HBV in this cohort but may be explained by the influence of viral coinfections on anti-HBs level or durability.

AB - To characterize predictors of isolated hepatitis B core antibody (anti-HBc) among human immunodeficiency virus (HIV)-infected and HIV-uninfected women, we compared 702 women with anti-HBc and hepatitis B surface antibody (anti-HBs) with 490 women with isolated anti-HBc (1.8% of whom had detectable hepatitis B virus [HBV] DNA). Factors independently associated with isolated anti-HBc without viremia were detectable hepatitis C virus (HCV) RNA, HIV positivity, history of injection drug use, >10 lifetime sex partners, and HIV RNA level >100,000 copies/mL. Anti-HBs levels were lower among anti-HCV-positive women. Isolated anti-HBc was rarely explained by occult HBV in this cohort but may be explained by the influence of viral coinfections on anti-HBs level or durability.

UR - http://www.scopus.com/inward/record.url?scp=34248161515&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34248161515&partnerID=8YFLogxK

U2 - 10.1086/515578

DO - 10.1086/515578

M3 - Article

C2 - 17436223

AN - SCOPUS:34248161515

VL - 195

SP - 1437

EP - 1442

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

IS - 10

ER -