Isolated hepatitis B core antibody is associated with HIV and ongoing but not resolved hepatitis C virus infection in a cohort of US women

Audrey L. French, Eva Operskalski, Marion Peters, Howard D. Strickler, Phyllis C. Tien, Gerald B. Sharp, Marshall J. Glesby, Mary Young, Michael Augenbraun, Eric Seaberg, Andrea Kovacs

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

To characterize predictors of isolated hepatitis B core antibody (anti-HBc) among human immunodeficiency virus (HIV)-infected and HIV-uninfected women, we compared 702 women with anti-HBc and hepatitis B surface antibody (anti-HBs) with 490 women with isolated anti-HBc (1.8% of whom had detectable hepatitis B virus [HBV] DNA). Factors independently associated with isolated anti-HBc without viremia were detectable hepatitis C virus (HCV) RNA, HIV positivity, history of injection drug use, >10 lifetime sex partners, and HIV RNA level >100,000 copies/mL. Anti-HBs levels were lower among anti-HCV-positive women. Isolated anti-HBc was rarely explained by occult HBV in this cohort but may be explained by the influence of viral coinfections on anti-HBs level or durability.

Original languageEnglish (US)
Pages (from-to)1437-1442
Number of pages6
JournalJournal of Infectious Diseases
Volume195
Issue number10
DOIs
StatePublished - May 15 2007

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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    French, A. L., Operskalski, E., Peters, M., Strickler, H. D., Tien, P. C., Sharp, G. B., Glesby, M. J., Young, M., Augenbraun, M., Seaberg, E., & Kovacs, A. (2007). Isolated hepatitis B core antibody is associated with HIV and ongoing but not resolved hepatitis C virus infection in a cohort of US women. Journal of Infectious Diseases, 195(10), 1437-1442. https://doi.org/10.1086/515578