ISN Nexus 2016 Symposia: Translational Immunology in Kidney Disease—The Berlin Roadmap

Hans Joachim Anders, Brad Rovin, David Jayne, Paul Brunetta, Rosanna Coppo, Anne Davidson, Satish Kumar Devarapu, Dick de Zeeuw, Jeremy Duffield, Dirk Eulberg, Alberto Fierro, Jürgen Floege, Steffen Frese, Loïc Guillevin, Stephen Holdsworth, Jeremy Hughes, Ralph Kettritz, Malte Kluger, Christian Krebs, Larissa LaptevaAdeera Levin, Jinhua Li, Liz Lightstone, Matthias Mack, Ladan Mansouri, Stephen McAdoo, Eoin McKinney, Ulf Panzer, Samir Parikh, Charles Pusey, Chaim Putterman, Ton Rabelink, Andreas Radbruch, Andrew Rees, Mary Reilly, Marlies Reinders, Giuseppe Remuzzi, Piero Ruggenenti, Steven Sacks, Thomas J. Schall, Catherine Meyer-Schwesinger, Kumar Sharma, Yusuke Suzuki, Nicola M. Tomas, Ming Hui Zhao

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

To date, the treatment of immune-mediated kidney diseases has only marginally benefited from highly specific biological drugs that have demonstrated remarkable effects in many other diseases. What accounts for this disparity? In April 2016, the International Society of Nephrology held a Nexus meeting on Translational Immunology in Nephrology in Berlin, Germany, to identify and discuss hurdles that block the translational flow of target identification, and preclinical and clinical target validation in the domain of immune-mediated kidney disease. A broad panel of experts including basic scientists, translational researchers, clinical trialists, pharmaceutical industry drug developers, and representatives of the American and European regulatory authorities made recommendations on how to overcome such hurdles at all levels of the translational research process. The results of these discussions are presented here, which may serve as a roadmap for how to optimize the process of developing more innovative and effective drugs for patients with immune-mediated kidney diseases.

Original languageEnglish (US)
Pages (from-to)327-339
Number of pages13
JournalKidney International Reports
Volume1
Issue number4
DOIs
StatePublished - Jan 1 2016

Keywords

  • autoimmunity
  • inflammation
  • lupus
  • rejection
  • stem cells
  • vasculitis

ASJC Scopus subject areas

  • Ophthalmology
  • Nephrology

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    Anders, H. J., Rovin, B., Jayne, D., Brunetta, P., Coppo, R., Davidson, A., Devarapu, S. K., de Zeeuw, D., Duffield, J., Eulberg, D., Fierro, A., Floege, J., Frese, S., Guillevin, L., Holdsworth, S., Hughes, J., Kettritz, R., Kluger, M., Krebs, C., ... Zhao, M. H. (2016). ISN Nexus 2016 Symposia: Translational Immunology in Kidney Disease—The Berlin Roadmap. Kidney International Reports, 1(4), 327-339. https://doi.org/10.1016/j.ekir.2016.06.009