Is there cumulative or delayed toxicity from Cis‐platinum?

Evidence of increasing risk of nephrotoxicity was sought in the records of 95 patients who had received 300–826 mg/m² cumulative doses of cis‐platinum in single doses of 50–75 mg/m² every 3–4 weeks, with hydration and diuresis using mannitol and furosemide. The incidence of serum creatinine elevation to >1.5 mg/dl was 4.2% per patient and 0.75% per dose, no higher than the incidence observed at lower cumulative doses. Among 54 of these patients observed for at least 3 months after cessation of cis‐platinum chemotherapy, only one had later deterioration of renal function to a serum creatinine of 1.9; both kidneys had been irradiated to 1900 rad in this patient. It was concluded that cumulative, delayed or severe nephrotoxicity are not significant problems related to prolonged cis‐platinum administration at moderate doses when hydration and diuretics are routinely used.