Is there a difference in survival for IA1 and IA2 adenocarcinoma of the uterine cervix?

Harriet O. Smith, Clifford R. Qualls, Audrey A. Romero, Joel C. Webb, Maxine H. Dorin, Luis A. Padilla, Charles R. Key

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Objective. The goal of this study was to determine if International Federation of Obstetrics and Gynecology (FIGO) subdivision into IA1 versus IA2 is predictive of survival differences for early invasive adenocarcinoma. Methods. The Surveillance, Epidemiology, and End-Results (SEER) Public-Use Database was used to identify all cases of IA1 and IA2 adenocarcinoma diagnosed between 1983 and 1997. A systematic literature search (MEDLINE 1966-2000) was used to identify all previously published cases. Stage, depth of invasion, node status, therapy, and survival were analyzed using Fisher's exact and log-rank tests. Results. In SEER, 560 cases were identified: 200 IA1, 286 IA2, and 74 localized. Simple hysterectomy was performed in 272 (48.6%) and radical hysterectomy in 210 (37.5%). Positive lymph nodes were found in 3 of 197 (1.5%) who underwent lymphadenectomy, 2 of whom died. The censored survival by stage (mean follow-up 51.6 months) was not significantly different (P = 0.77) for IA1 versus IA2 (98.5% vs 98.6%). Combining these data with all other published series of early cervical adenocarcinoma, 1170 cases were identified, including 585 IA1, 358 IA2, and 227 "others," with less defined early disease. Of 531 (45.4%) who underwent lymphadenectomy, 15 (1.28%) had one or more positive nodes; of these, 11 (73.3%) recurred or died. For IA1 versus IA2 disease, there were no significant differences in the frequency of positive lymph nodes, recurrence, or death. However, "others," those with less well-defined lesions, or larger than IA2, were at increased risk. Conclusion. Early invasive adenocarcinoma (IA1 and IA2) has an excellent prognosis and conservative surgery may be appropriate. Since current FIGO staging definitions do not distinguish high- from low-risk disease, individualization of therapy based on pathology review, risk assessment, and patient preference is recommended.

Original languageEnglish (US)
Pages (from-to)229-241
Number of pages13
JournalGynecologic Oncology
Volume85
Issue number2
DOIs
StatePublished - 2002
Externally publishedYes

Fingerprint

Cervix Uteri
Adenocarcinoma
Lymph Node Excision
Hysterectomy
Gynecology
Obstetrics
Epidemiology
Lymph Nodes
Patient Preference
MEDLINE
Databases
Pathology
Recurrence
Therapeutics

Keywords

  • Adenocarcinoma
  • Cervix
  • FIGO IA1, IA2 disease
  • Hysterectomy
  • Microinvasive

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Oncology

Cite this

Smith, H. O., Qualls, C. R., Romero, A. A., Webb, J. C., Dorin, M. H., Padilla, L. A., & Key, C. R. (2002). Is there a difference in survival for IA1 and IA2 adenocarcinoma of the uterine cervix? Gynecologic Oncology, 85(2), 229-241. https://doi.org/10.1006/gyno.2002.6635

Is there a difference in survival for IA1 and IA2 adenocarcinoma of the uterine cervix? / Smith, Harriet O.; Qualls, Clifford R.; Romero, Audrey A.; Webb, Joel C.; Dorin, Maxine H.; Padilla, Luis A.; Key, Charles R.

In: Gynecologic Oncology, Vol. 85, No. 2, 2002, p. 229-241.

Research output: Contribution to journalArticle

Smith, HO, Qualls, CR, Romero, AA, Webb, JC, Dorin, MH, Padilla, LA & Key, CR 2002, 'Is there a difference in survival for IA1 and IA2 adenocarcinoma of the uterine cervix?', Gynecologic Oncology, vol. 85, no. 2, pp. 229-241. https://doi.org/10.1006/gyno.2002.6635
Smith, Harriet O. ; Qualls, Clifford R. ; Romero, Audrey A. ; Webb, Joel C. ; Dorin, Maxine H. ; Padilla, Luis A. ; Key, Charles R. / Is there a difference in survival for IA1 and IA2 adenocarcinoma of the uterine cervix?. In: Gynecologic Oncology. 2002 ; Vol. 85, No. 2. pp. 229-241.
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abstract = "Objective. The goal of this study was to determine if International Federation of Obstetrics and Gynecology (FIGO) subdivision into IA1 versus IA2 is predictive of survival differences for early invasive adenocarcinoma. Methods. The Surveillance, Epidemiology, and End-Results (SEER) Public-Use Database was used to identify all cases of IA1 and IA2 adenocarcinoma diagnosed between 1983 and 1997. A systematic literature search (MEDLINE 1966-2000) was used to identify all previously published cases. Stage, depth of invasion, node status, therapy, and survival were analyzed using Fisher's exact and log-rank tests. Results. In SEER, 560 cases were identified: 200 IA1, 286 IA2, and 74 localized. Simple hysterectomy was performed in 272 (48.6{\%}) and radical hysterectomy in 210 (37.5{\%}). Positive lymph nodes were found in 3 of 197 (1.5{\%}) who underwent lymphadenectomy, 2 of whom died. The censored survival by stage (mean follow-up 51.6 months) was not significantly different (P = 0.77) for IA1 versus IA2 (98.5{\%} vs 98.6{\%}). Combining these data with all other published series of early cervical adenocarcinoma, 1170 cases were identified, including 585 IA1, 358 IA2, and 227 {"}others,{"} with less defined early disease. Of 531 (45.4{\%}) who underwent lymphadenectomy, 15 (1.28{\%}) had one or more positive nodes; of these, 11 (73.3{\%}) recurred or died. For IA1 versus IA2 disease, there were no significant differences in the frequency of positive lymph nodes, recurrence, or death. However, {"}others,{"} those with less well-defined lesions, or larger than IA2, were at increased risk. Conclusion. Early invasive adenocarcinoma (IA1 and IA2) has an excellent prognosis and conservative surgery may be appropriate. Since current FIGO staging definitions do not distinguish high- from low-risk disease, individualization of therapy based on pathology review, risk assessment, and patient preference is recommended.",
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