Is the EFNB2 locus associated with schizophrenia? Single nucleotide polymorphisms and haplotypes analysis

Rui Zhang; Nan Nan Zhong; Xiao Gang Liu; Han Yan; Chuan Qiu; Yan Han; Wei Wang; Wei Kun Hou; Yue Liu; Cheng Ge Gao; Ting Wei Guo; She Min Lu; Hong Wen Deng; Jie Ma

doi:10.1016/j.psychres.2010.04.037

Is the EFNB2 locus associated with schizophrenia? Single nucleotide polymorphisms and haplotypes analysis

Rui Zhang, Nan Nan Zhong, Xiao Gang Liu, Han Yan, Chuan Qiu, Yan Han, Wei Wang, Wei Kun Hou, Yue Liu, Cheng Ge Gao, Ting Wei Guo, She Min Lu, Hong Wen Deng, Jie Ma

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Recently, evidence of linkage of schizophrenia to chromosome 13q22-q34 has been demonstrated in multiple studies. Based on structure and function, EFNB2 may be considered as a compelling candidate gene for schizophrenia on chromosome 13q33. We genotyped three single-nucleotide polymorphisms (SNPs: rs9520087, rs11069646, and rs8000078) in this region in 846 Han Chinese subjects (477 cases and 369 controls). Significant association between an allele of marker rs9520087 and schizophrenia was found. Furthermore, since no LD was observed in the three SNPs linkage disequilibrium estimation, all three SNPs were used in multiple SNPs haplotype analysis, and a strongly significant difference was found for the common haplotype TTC. Overall our findings indicate that EFNB2 gene may be a candidate susceptibility gene for schizophrenia in the Han Chinese population, and also provide further support for the potential importance of the NMDA receptor pathway in the etiology of schizophrenia.

Original language	English (US)
Pages (from-to)	5-9
Number of pages	5
Journal	Psychiatry Research
Volume	180
Issue number	1
DOIs	https://doi.org/10.1016/j.psychres.2010.04.037
State	Published - Nov 30 2010
Externally published	Yes

Keywords

Association
EFNB2
Haplotype
NMDA
SNP
Schizophrenia

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.psychres.2010.04.037

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title = "Is the EFNB2 locus associated with schizophrenia? Single nucleotide polymorphisms and haplotypes analysis",

abstract = "Recently, evidence of linkage of schizophrenia to chromosome 13q22-q34 has been demonstrated in multiple studies. Based on structure and function, EFNB2 may be considered as a compelling candidate gene for schizophrenia on chromosome 13q33. We genotyped three single-nucleotide polymorphisms (SNPs: rs9520087, rs11069646, and rs8000078) in this region in 846 Han Chinese subjects (477 cases and 369 controls). Significant association between an allele of marker rs9520087 and schizophrenia was found. Furthermore, since no LD was observed in the three SNPs linkage disequilibrium estimation, all three SNPs were used in multiple SNPs haplotype analysis, and a strongly significant difference was found for the common haplotype TTC. Overall our findings indicate that EFNB2 gene may be a candidate susceptibility gene for schizophrenia in the Han Chinese population, and also provide further support for the potential importance of the NMDA receptor pathway in the etiology of schizophrenia.",

keywords = "Association, EFNB2, Haplotype, NMDA, SNP, Schizophrenia",

author = "Rui Zhang and Zhong, {Nan Nan} and Liu, {Xiao Gang} and Han Yan and Chuan Qiu and Yan Han and Wei Wang and Hou, {Wei Kun} and Yue Liu and Gao, {Cheng Ge} and Guo, {Ting Wei} and Lu, {She Min} and Deng, {Hong Wen} and Jie Ma",

note = "Funding Information: We are deeply grateful to all of the families who participated in this study, as well as to the psychiatrists and mental health workers who helped us with the identification of the families. This work was supported by grants from the Ministry of Education, PRC (No. 20090201120062 ), the National Natural Science Foundation of China (No. 30800618 ), and the Headmaster Fundation of Xi'an Jiaotong University .",

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doi = "10.1016/j.psychres.2010.04.037",

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T1 - Is the EFNB2 locus associated with schizophrenia? Single nucleotide polymorphisms and haplotypes analysis

AU - Zhang, Rui

AU - Zhong, Nan Nan

AU - Liu, Xiao Gang

AU - Yan, Han

AU - Qiu, Chuan

AU - Han, Yan

AU - Wang, Wei

AU - Hou, Wei Kun

AU - Liu, Yue

AU - Gao, Cheng Ge

AU - Guo, Ting Wei

AU - Lu, She Min

AU - Deng, Hong Wen

AU - Ma, Jie

N1 - Funding Information: We are deeply grateful to all of the families who participated in this study, as well as to the psychiatrists and mental health workers who helped us with the identification of the families. This work was supported by grants from the Ministry of Education, PRC (No. 20090201120062 ), the National Natural Science Foundation of China (No. 30800618 ), and the Headmaster Fundation of Xi'an Jiaotong University .

PY - 2010/11/30

Y1 - 2010/11/30

N2 - Recently, evidence of linkage of schizophrenia to chromosome 13q22-q34 has been demonstrated in multiple studies. Based on structure and function, EFNB2 may be considered as a compelling candidate gene for schizophrenia on chromosome 13q33. We genotyped three single-nucleotide polymorphisms (SNPs: rs9520087, rs11069646, and rs8000078) in this region in 846 Han Chinese subjects (477 cases and 369 controls). Significant association between an allele of marker rs9520087 and schizophrenia was found. Furthermore, since no LD was observed in the three SNPs linkage disequilibrium estimation, all three SNPs were used in multiple SNPs haplotype analysis, and a strongly significant difference was found for the common haplotype TTC. Overall our findings indicate that EFNB2 gene may be a candidate susceptibility gene for schizophrenia in the Han Chinese population, and also provide further support for the potential importance of the NMDA receptor pathway in the etiology of schizophrenia.

AB - Recently, evidence of linkage of schizophrenia to chromosome 13q22-q34 has been demonstrated in multiple studies. Based on structure and function, EFNB2 may be considered as a compelling candidate gene for schizophrenia on chromosome 13q33. We genotyped three single-nucleotide polymorphisms (SNPs: rs9520087, rs11069646, and rs8000078) in this region in 846 Han Chinese subjects (477 cases and 369 controls). Significant association between an allele of marker rs9520087 and schizophrenia was found. Furthermore, since no LD was observed in the three SNPs linkage disequilibrium estimation, all three SNPs were used in multiple SNPs haplotype analysis, and a strongly significant difference was found for the common haplotype TTC. Overall our findings indicate that EFNB2 gene may be a candidate susceptibility gene for schizophrenia in the Han Chinese population, and also provide further support for the potential importance of the NMDA receptor pathway in the etiology of schizophrenia.

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KW - SNP

KW - Schizophrenia

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Is the EFNB2 locus associated with schizophrenia? Single nucleotide polymorphisms and haplotypes analysis

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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