Is the EFNB2 locus associated with schizophrenia? Single nucleotide polymorphisms and haplotypes analysis

Rui Zhang, Nan Nan Zhong, Xiao Gang Liu, Han Yan, Chuan Qiu, Yan Han, Wei Wang, Wei Kun Hou, Yue Liu, Cheng Ge Gao, Ting Wei Guo, She Min Lu, Hong Wen Deng, Jie Ma

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Recently, evidence of linkage of schizophrenia to chromosome 13q22-q34 has been demonstrated in multiple studies. Based on structure and function, EFNB2 may be considered as a compelling candidate gene for schizophrenia on chromosome 13q33. We genotyped three single-nucleotide polymorphisms (SNPs: rs9520087, rs11069646, and rs8000078) in this region in 846 Han Chinese subjects (477 cases and 369 controls). Significant association between an allele of marker rs9520087 and schizophrenia was found. Furthermore, since no LD was observed in the three SNPs linkage disequilibrium estimation, all three SNPs were used in multiple SNPs haplotype analysis, and a strongly significant difference was found for the common haplotype TTC. Overall our findings indicate that EFNB2 gene may be a candidate susceptibility gene for schizophrenia in the Han Chinese population, and also provide further support for the potential importance of the NMDA receptor pathway in the etiology of schizophrenia.

Original languageEnglish (US)
Pages (from-to)5-9
Number of pages5
JournalPsychiatry Research
Volume180
Issue number1
DOIs
StatePublished - Nov 30 2010
Externally publishedYes

Fingerprint

Haplotypes
Single Nucleotide Polymorphism
Schizophrenia
Chromosomes
Genes
Linkage Disequilibrium
N-Methyl-D-Aspartate Receptors
Alleles
Population

Keywords

  • Association
  • EFNB2
  • Haplotype
  • NMDA
  • Schizophrenia
  • SNP

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Is the EFNB2 locus associated with schizophrenia? Single nucleotide polymorphisms and haplotypes analysis. / Zhang, Rui; Zhong, Nan Nan; Liu, Xiao Gang; Yan, Han; Qiu, Chuan; Han, Yan; Wang, Wei; Hou, Wei Kun; Liu, Yue; Gao, Cheng Ge; Guo, Ting Wei; Lu, She Min; Deng, Hong Wen; Ma, Jie.

In: Psychiatry Research, Vol. 180, No. 1, 30.11.2010, p. 5-9.

Research output: Contribution to journalArticle

Zhang, R, Zhong, NN, Liu, XG, Yan, H, Qiu, C, Han, Y, Wang, W, Hou, WK, Liu, Y, Gao, CG, Guo, TW, Lu, SM, Deng, HW & Ma, J 2010, 'Is the EFNB2 locus associated with schizophrenia? Single nucleotide polymorphisms and haplotypes analysis', Psychiatry Research, vol. 180, no. 1, pp. 5-9. https://doi.org/10.1016/j.psychres.2010.04.037
Zhang, Rui ; Zhong, Nan Nan ; Liu, Xiao Gang ; Yan, Han ; Qiu, Chuan ; Han, Yan ; Wang, Wei ; Hou, Wei Kun ; Liu, Yue ; Gao, Cheng Ge ; Guo, Ting Wei ; Lu, She Min ; Deng, Hong Wen ; Ma, Jie. / Is the EFNB2 locus associated with schizophrenia? Single nucleotide polymorphisms and haplotypes analysis. In: Psychiatry Research. 2010 ; Vol. 180, No. 1. pp. 5-9.
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AU - Wang, Wei

AU - Hou, Wei Kun

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AU - Gao, Cheng Ge

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