Is the conserved mammalian region of ZNF804A locus associated with schizophrenia? A population-based genetics analysis

Rui Zhang, Robert K. Valenzuela, Shemin Lu, Liesu Meng, Tingwei Guo, Xiaoyun Du, Wanhu Kang, Jie Ma

Research output: Contribution to journalArticle

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Abstract

Recently, several genome-wide association studies (GWASs) have reproduced the significant association of the single nucleotide polymorphism (SNP) rs1344706 (located in intron 2 of the zinc finger protein 804A (ZNF804A) on chromosome 2q32.1) with schizophrenia. Bioinformatic analysis of the chromosome segment around rs1344706 suggests that a short conserved mammalian region exists approximately 3. kb downstream of rs1344706. In the present work, we studied all SNPs in this conserved mammalian region and performed genetic analyses on samples from Chinese schizophrenia patients (n = 516) and compared control subjects (n = 520). Significant association between an allele of rs13423388 and schizophrenia was found (P= 0.0012). Haplotype analysis of the three SNPs rs4666998, rs13423388, and rs56280129 showed significant associations with schizophrenia (global P= 0.00001). Furthermore, we performed a four-SNP haplotype analysis which included the SNPs from the three-SNP haplotype analysis and rs1344706 (global P= 0.0005), and found that haplotype GCCG was associated with schizophrenia (P= 0.003). In summary, the present study adds new evidence for an association between the conserved mammalian region of the ZNF804A gene and schizophrenia. Further research is needed to clarify the transcriptional regulation of ZNF804A gene and to relate this to the pathophysiology of schizophrenia.

Original languageEnglish (US)
Pages (from-to)159-164
Number of pages6
JournalSchizophrenia Research
Volume133
Issue number1-3
DOIs
StatePublished - Dec 2011

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Zinc Fingers
Population Genetics
Schizophrenia
Single Nucleotide Polymorphism
Haplotypes
Proteins
Chromosomes
Genome-Wide Association Study
Computational Biology
Introns
Alleles
Research

Keywords

  • Conserved region
  • Haplotype
  • Schizophrenia
  • SNPs
  • ZNF804A

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Is the conserved mammalian region of ZNF804A locus associated with schizophrenia? A population-based genetics analysis. / Zhang, Rui; Valenzuela, Robert K.; Lu, Shemin; Meng, Liesu; Guo, Tingwei; Du, Xiaoyun; Kang, Wanhu; Ma, Jie.

In: Schizophrenia Research, Vol. 133, No. 1-3, 12.2011, p. 159-164.

Research output: Contribution to journalArticle

Zhang, Rui ; Valenzuela, Robert K. ; Lu, Shemin ; Meng, Liesu ; Guo, Tingwei ; Du, Xiaoyun ; Kang, Wanhu ; Ma, Jie. / Is the conserved mammalian region of ZNF804A locus associated with schizophrenia? A population-based genetics analysis. In: Schizophrenia Research. 2011 ; Vol. 133, No. 1-3. pp. 159-164.
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