TY - JOUR
T1 - Is the conserved mammalian region of ZNF804A locus associated with schizophrenia? A population-based genetics analysis
AU - Zhang, Rui
AU - Valenzuela, Robert K.
AU - Lu, Shemin
AU - Meng, Liesu
AU - Guo, Tingwei
AU - Du, Xiaoyun
AU - Kang, Wanhu
AU - Ma, Jie
N1 - Funding Information:
We are indebted to all individuals who have participated in, or helped with, our research. This study was supported by funding from the National Natural Science Foundation of China (No. 30800618 ), the Ministry of Education, PRC (No. 20090201120062 ), the National Innovation Experiment Program for University Students (No. 101069863 ), and the President Foundation of Xi'an Jiaotong University (No. XJJ2008005 ).
Funding Information:
This study was supported by funding from the National Natural Science Foundation of China (No. 30800618), the Ministry of Education, PRC (No. 20090201120062), the National Innovation Experiment Program for University Students (No. 101069863), and the President Foundation of Xi'an Jiaotong University (No. XJJ2008005).
PY - 2011/12
Y1 - 2011/12
N2 - Recently, several genome-wide association studies (GWASs) have reproduced the significant association of the single nucleotide polymorphism (SNP) rs1344706 (located in intron 2 of the zinc finger protein 804A (ZNF804A) on chromosome 2q32.1) with schizophrenia. Bioinformatic analysis of the chromosome segment around rs1344706 suggests that a short conserved mammalian region exists approximately 3. kb downstream of rs1344706. In the present work, we studied all SNPs in this conserved mammalian region and performed genetic analyses on samples from Chinese schizophrenia patients (n = 516) and compared control subjects (n = 520). Significant association between an allele of rs13423388 and schizophrenia was found (P= 0.0012). Haplotype analysis of the three SNPs rs4666998, rs13423388, and rs56280129 showed significant associations with schizophrenia (global P= 0.00001). Furthermore, we performed a four-SNP haplotype analysis which included the SNPs from the three-SNP haplotype analysis and rs1344706 (global P= 0.0005), and found that haplotype GCCG was associated with schizophrenia (P= 0.003). In summary, the present study adds new evidence for an association between the conserved mammalian region of the ZNF804A gene and schizophrenia. Further research is needed to clarify the transcriptional regulation of ZNF804A gene and to relate this to the pathophysiology of schizophrenia.
AB - Recently, several genome-wide association studies (GWASs) have reproduced the significant association of the single nucleotide polymorphism (SNP) rs1344706 (located in intron 2 of the zinc finger protein 804A (ZNF804A) on chromosome 2q32.1) with schizophrenia. Bioinformatic analysis of the chromosome segment around rs1344706 suggests that a short conserved mammalian region exists approximately 3. kb downstream of rs1344706. In the present work, we studied all SNPs in this conserved mammalian region and performed genetic analyses on samples from Chinese schizophrenia patients (n = 516) and compared control subjects (n = 520). Significant association between an allele of rs13423388 and schizophrenia was found (P= 0.0012). Haplotype analysis of the three SNPs rs4666998, rs13423388, and rs56280129 showed significant associations with schizophrenia (global P= 0.00001). Furthermore, we performed a four-SNP haplotype analysis which included the SNPs from the three-SNP haplotype analysis and rs1344706 (global P= 0.0005), and found that haplotype GCCG was associated with schizophrenia (P= 0.003). In summary, the present study adds new evidence for an association between the conserved mammalian region of the ZNF804A gene and schizophrenia. Further research is needed to clarify the transcriptional regulation of ZNF804A gene and to relate this to the pathophysiology of schizophrenia.
KW - Conserved region
KW - Haplotype
KW - SNPs
KW - Schizophrenia
KW - ZNF804A
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U2 - 10.1016/j.schres.2011.09.012
DO - 10.1016/j.schres.2011.09.012
M3 - Article
C2 - 21993378
AN - SCOPUS:81955167489
SN - 0920-9964
VL - 133
SP - 159
EP - 164
JO - Schizophrenia Research
JF - Schizophrenia Research
IS - 1-3
ER -
