Is inflammation good for the ischemic heart - Perspectives beyond the ordinary

M. L. Entman, K. A. Youker, Nikolaos G. Frangogiannis, V. Lakshminarayanan, T. Nossuli, A. Evans, K. Kurrelmeyer, D. L. Mann, C. W. Smith

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

In recent years, early reperfusion of the myocardial infarct has become the mainstay of optimal therapeutic management since it limits ventricular injury and infarct expansion and improves patient survival [14]. It has become clear that reperfusion promotes effective tissue repair and decreases ventricular remodeling even under circumstances where reperfusion is effected at too late a time to limit myocardial necrosis [4]. One of the striking differences between reperfused and non-reperfused myocardial infarctions is that the early intense inflammatory reaction which ensues immediately upon reperfusion has been demonstrated to potentially extend myocardial injury [9]. Substantial evidence suggests that this inflammatory reaction is important in tissue repair, leading to an obvious paradox with regard to the role of the inflammatory reaction. This communication takes the position that inflammatory injury occurring upon reperfusion of the infarcted myocardium results from the overwhelming of tissue defenses against inflammation resulting from the sudden entry of large amounts of neutrophils to an area of infarction where chemotactic factors have built up to high concentration. However, we hypothesize that inflammation fundamentally evolved as a protective mechanism to promote tissue healing and protect jeopardized myocardium. In this presentation, we will discuss our approach and data designed to evaluate potential protective roles of the inflammatory reaction after reperfusion.

Original languageEnglish (US)
JournalZeitschrift fur Kardiologie
Volume89
Issue numberSUPPL. 9
DOIs
StatePublished - 2000
Externally publishedYes

Fingerprint

Reperfusion
Inflammation
Myocardium
Wounds and Injuries
Myocardial Infarction
Ventricular Remodeling
Chemotactic Factors
Infarction
Neutrophils
Necrosis
Survival

Keywords

  • Inflammation
  • Myocardial infarct
  • Reperfusion
  • Tissue repair

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Entman, M. L., Youker, K. A., Frangogiannis, N. G., Lakshminarayanan, V., Nossuli, T., Evans, A., ... Smith, C. W. (2000). Is inflammation good for the ischemic heart - Perspectives beyond the ordinary. Zeitschrift fur Kardiologie, 89(SUPPL. 9). https://doi.org/10.1007/s003920070036

Is inflammation good for the ischemic heart - Perspectives beyond the ordinary. / Entman, M. L.; Youker, K. A.; Frangogiannis, Nikolaos G.; Lakshminarayanan, V.; Nossuli, T.; Evans, A.; Kurrelmeyer, K.; Mann, D. L.; Smith, C. W.

In: Zeitschrift fur Kardiologie, Vol. 89, No. SUPPL. 9, 2000.

Research output: Contribution to journalArticle

Entman, ML, Youker, KA, Frangogiannis, NG, Lakshminarayanan, V, Nossuli, T, Evans, A, Kurrelmeyer, K, Mann, DL & Smith, CW 2000, 'Is inflammation good for the ischemic heart - Perspectives beyond the ordinary', Zeitschrift fur Kardiologie, vol. 89, no. SUPPL. 9. https://doi.org/10.1007/s003920070036
Entman, M. L. ; Youker, K. A. ; Frangogiannis, Nikolaos G. ; Lakshminarayanan, V. ; Nossuli, T. ; Evans, A. ; Kurrelmeyer, K. ; Mann, D. L. ; Smith, C. W. / Is inflammation good for the ischemic heart - Perspectives beyond the ordinary. In: Zeitschrift fur Kardiologie. 2000 ; Vol. 89, No. SUPPL. 9.
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