Is immobilization associated with an abnormal lipoprotein profile? Observations from a diverse cohort

W. A. Bauman, R. H. Adkins, A. M. Spungen, R. Herbert, Clyde B. Schechter, D. Smith, B. J. Kemp, R. Gambino, P. Maloney, R. L. Waters

Research output: Contribution to journalArticle

88 Citations (Scopus)

Abstract

Objective: The potential effects of ethnicity, gender, and adiposity on the serum lipid profile in persons with spinal cord injury (SCI) were determined. Subjects: Subjects with SCI were recruited during their annual physical examination from Rancho Los Amigos Medical Center, Downey, California. Sedentary able-bodied controls were Bridge and Tunnel Officers of the Triboro Bridge and Tunnel Authority of the New York City metropolitan area. Methods: Serum lipid profiles were investigated in 320 subjects with SCI and compared to those obtained from 303 relatively sedentary able-bodied controls. Serum lipid studies were obtained in the fasting state. Data were collected between 1993 and 1996. All lipid determinations were performed by the same commercial laboratory. Main outcome measures: The dependent variables were the values from the lipid profile analysis. The independent variables consisted of study group, gender, ethnic group, age, duration of injury, and anthropometric measurements. Results: The serum high-density lipoprotein cholesterol (HDL-c) level was reduced in the SCI compared with the control group (mean ± SEM) (42 ± 0.79 vs 47 ± 0.67 mg/dl, P < 0.0005). The serum HDL-c level was significantly lower in males with SCI than males in the control group (39 ± 0.83 vs 45 ± 0.70 mg/dl, P < 0.0001), but not for females (51 ± 1.54 vs 54 ± 1.52 mg/dl, n.s.). Within the subgroups for whites and Latinos, HDL-c values were also lower in subjects with SCI than in controls (whites: 41 ± 1.02 vs 46 ± 0.86 mg/dl, P < 0.0001; Latinos: 37 ± 1.53 vs 42 ± 1.59 mg/dl, P < 0.05), but not for African Americans (49 ± 1.56 vs 51 ± 1.27 mg/dl, n.s.). African Americans had higher HDL-c values than whites or Latinos (SCI: 49 ± 1.56 vs 41 ± 1.02 or 37 ± 1.53 mg/dl, P < 0.0001; controls: 51 ± 1.27 vs 46 ± 0.86 mg/dl, P < 0.01 or 42 ± 1.59 mg/dl, P < 0.0005). In persons with SCI, the serum HDL-c values were inversely related to body mass index and estimated per cent body fat (r = 0.27, P < 0.0001). Conclusion: In white and Latino males, but not in females or African Americans, immobilization from SCI appears to be associated with lower HDL-c values than in controls.

Original languageEnglish (US)
Pages (from-to)485-493
Number of pages9
JournalSpinal Cord
Volume37
Issue number7
StatePublished - 1999
Externally publishedYes

Fingerprint

Spinal Cord Injuries
Immobilization
Lipoproteins
HDL Cholesterol
Hispanic Americans
Lipids
Serum
African Americans
Control Groups
Adiposity
Ethnic Groups
Physical Examination
Adipose Tissue
Fasting
Body Mass Index
Outcome Assessment (Health Care)
Wounds and Injuries

Keywords

  • Coronary heart disease
  • Ethnicity
  • Gender
  • High density lipoprotein cholesterol
  • Spinal cord injury

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Bauman, W. A., Adkins, R. H., Spungen, A. M., Herbert, R., Schechter, C. B., Smith, D., ... Waters, R. L. (1999). Is immobilization associated with an abnormal lipoprotein profile? Observations from a diverse cohort. Spinal Cord, 37(7), 485-493.

Is immobilization associated with an abnormal lipoprotein profile? Observations from a diverse cohort. / Bauman, W. A.; Adkins, R. H.; Spungen, A. M.; Herbert, R.; Schechter, Clyde B.; Smith, D.; Kemp, B. J.; Gambino, R.; Maloney, P.; Waters, R. L.

In: Spinal Cord, Vol. 37, No. 7, 1999, p. 485-493.

Research output: Contribution to journalArticle

Bauman, WA, Adkins, RH, Spungen, AM, Herbert, R, Schechter, CB, Smith, D, Kemp, BJ, Gambino, R, Maloney, P & Waters, RL 1999, 'Is immobilization associated with an abnormal lipoprotein profile? Observations from a diverse cohort', Spinal Cord, vol. 37, no. 7, pp. 485-493.
Bauman, W. A. ; Adkins, R. H. ; Spungen, A. M. ; Herbert, R. ; Schechter, Clyde B. ; Smith, D. ; Kemp, B. J. ; Gambino, R. ; Maloney, P. ; Waters, R. L. / Is immobilization associated with an abnormal lipoprotein profile? Observations from a diverse cohort. In: Spinal Cord. 1999 ; Vol. 37, No. 7. pp. 485-493.
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abstract = "Objective: The potential effects of ethnicity, gender, and adiposity on the serum lipid profile in persons with spinal cord injury (SCI) were determined. Subjects: Subjects with SCI were recruited during their annual physical examination from Rancho Los Amigos Medical Center, Downey, California. Sedentary able-bodied controls were Bridge and Tunnel Officers of the Triboro Bridge and Tunnel Authority of the New York City metropolitan area. Methods: Serum lipid profiles were investigated in 320 subjects with SCI and compared to those obtained from 303 relatively sedentary able-bodied controls. Serum lipid studies were obtained in the fasting state. Data were collected between 1993 and 1996. All lipid determinations were performed by the same commercial laboratory. Main outcome measures: The dependent variables were the values from the lipid profile analysis. The independent variables consisted of study group, gender, ethnic group, age, duration of injury, and anthropometric measurements. Results: The serum high-density lipoprotein cholesterol (HDL-c) level was reduced in the SCI compared with the control group (mean ± SEM) (42 ± 0.79 vs 47 ± 0.67 mg/dl, P < 0.0005). The serum HDL-c level was significantly lower in males with SCI than males in the control group (39 ± 0.83 vs 45 ± 0.70 mg/dl, P < 0.0001), but not for females (51 ± 1.54 vs 54 ± 1.52 mg/dl, n.s.). Within the subgroups for whites and Latinos, HDL-c values were also lower in subjects with SCI than in controls (whites: 41 ± 1.02 vs 46 ± 0.86 mg/dl, P < 0.0001; Latinos: 37 ± 1.53 vs 42 ± 1.59 mg/dl, P < 0.05), but not for African Americans (49 ± 1.56 vs 51 ± 1.27 mg/dl, n.s.). African Americans had higher HDL-c values than whites or Latinos (SCI: 49 ± 1.56 vs 41 ± 1.02 or 37 ± 1.53 mg/dl, P < 0.0001; controls: 51 ± 1.27 vs 46 ± 0.86 mg/dl, P < 0.01 or 42 ± 1.59 mg/dl, P < 0.0005). In persons with SCI, the serum HDL-c values were inversely related to body mass index and estimated per cent body fat (r = 0.27, P < 0.0001). Conclusion: In white and Latino males, but not in females or African Americans, immobilization from SCI appears to be associated with lower HDL-c values than in controls.",
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T1 - Is immobilization associated with an abnormal lipoprotein profile? Observations from a diverse cohort

AU - Bauman, W. A.

AU - Adkins, R. H.

AU - Spungen, A. M.

AU - Herbert, R.

AU - Schechter, Clyde B.

AU - Smith, D.

AU - Kemp, B. J.

AU - Gambino, R.

AU - Maloney, P.

AU - Waters, R. L.

PY - 1999

Y1 - 1999

N2 - Objective: The potential effects of ethnicity, gender, and adiposity on the serum lipid profile in persons with spinal cord injury (SCI) were determined. Subjects: Subjects with SCI were recruited during their annual physical examination from Rancho Los Amigos Medical Center, Downey, California. Sedentary able-bodied controls were Bridge and Tunnel Officers of the Triboro Bridge and Tunnel Authority of the New York City metropolitan area. Methods: Serum lipid profiles were investigated in 320 subjects with SCI and compared to those obtained from 303 relatively sedentary able-bodied controls. Serum lipid studies were obtained in the fasting state. Data were collected between 1993 and 1996. All lipid determinations were performed by the same commercial laboratory. Main outcome measures: The dependent variables were the values from the lipid profile analysis. The independent variables consisted of study group, gender, ethnic group, age, duration of injury, and anthropometric measurements. Results: The serum high-density lipoprotein cholesterol (HDL-c) level was reduced in the SCI compared with the control group (mean ± SEM) (42 ± 0.79 vs 47 ± 0.67 mg/dl, P < 0.0005). The serum HDL-c level was significantly lower in males with SCI than males in the control group (39 ± 0.83 vs 45 ± 0.70 mg/dl, P < 0.0001), but not for females (51 ± 1.54 vs 54 ± 1.52 mg/dl, n.s.). Within the subgroups for whites and Latinos, HDL-c values were also lower in subjects with SCI than in controls (whites: 41 ± 1.02 vs 46 ± 0.86 mg/dl, P < 0.0001; Latinos: 37 ± 1.53 vs 42 ± 1.59 mg/dl, P < 0.05), but not for African Americans (49 ± 1.56 vs 51 ± 1.27 mg/dl, n.s.). African Americans had higher HDL-c values than whites or Latinos (SCI: 49 ± 1.56 vs 41 ± 1.02 or 37 ± 1.53 mg/dl, P < 0.0001; controls: 51 ± 1.27 vs 46 ± 0.86 mg/dl, P < 0.01 or 42 ± 1.59 mg/dl, P < 0.0005). In persons with SCI, the serum HDL-c values were inversely related to body mass index and estimated per cent body fat (r = 0.27, P < 0.0001). Conclusion: In white and Latino males, but not in females or African Americans, immobilization from SCI appears to be associated with lower HDL-c values than in controls.

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KW - Coronary heart disease

KW - Ethnicity

KW - Gender

KW - High density lipoprotein cholesterol

KW - Spinal cord injury

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