Is fructose malabsorption a cause of irritable bowel syndrome?

James J. DiNicolantonio, Sean C. Lucan

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Irritable Bowel Syndrome (IBS) is a condition that may be marked by abdominal pain, bloating, fullness, indigestion, belching, constipation and/or diarrhea. IBS symptoms can result from malabsorption of fructose. Fructose is a monosaccharide found naturally in small quantities in fruits and some vegetables, and in much larger quantities in industrially manufactured sweets with added sugars (e.g. sucrose and high fructose corn syrup). Fructose malabsorption leads to osmotic diarrhea as well as gas and bloating due to fermentation in the colon. A low-fructose diet has been found to improve IBS symptoms in some patients. This paper discusses the prevalence of fructose malabsorption and considers fructose ingestion as a possible cause of--and fructose restriction as a possible dietary treatment for--IBS.

Original languageEnglish (US)
Pages (from-to)295-297
Number of pages3
JournalMedical Hypotheses
Issue number3
StatePublished - Sep 1 2015
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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