Iron sucrose induced morphological and functional changes in the rat kidney

Andrzej Breborowicz, Alicja Polubinska, Kinga Górna, Maciej Breborowicz, Dimitrios G. Oreopoulos

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Treatment of anemia in uremic patients requires simultaneous supplementation of erythropoietin and iron. Because of the impaired iron absorption from the gastrointestinal tract in conditions of renal insufficiency, intravenous supplementation is a treatment of choice in such conditions. Iron compounds used for intravenous supplementation induce several systemic side effects, and therefore, we studied the effect of chronic exposure to iron sucrose in rats on renal function. Experiments were performed on male Wistar rats, which were infused intraperitoneally every 4 days, for 28 days with iron sucrose in a dose 1 mg/kg bw or 10 mg/kg bw diluted in 20 mL of the dialysis fluid. Control animals were infused with plain dialysis fluid. Renal function was evaluated at the beginning and at the end of the study. Additionally morphology of the kidneys was evaluated in all animals after 28 days of the study. Chronic exposure of rats to iron sucrose resulted in increased accumulation of PAS-positive material in their glomeruli: + 38% at Fe 1mg/kg bw P < 0.05 and + 42% at Fe 10 mg/kg/bw P < 0.01 and collagen in the peritubular area: + 40% at Fe 1mg/kg bw P < 0.005 and + 77% at Fe 10 mg/kg/bw P < 0.001. Only renal clearance of urea was decreased by 53%, P < 0.01 in rats exposed to iron sucrose at a dose of 10 mg/kg bw. Chronic exposure of rats to iron sucrose results in morphologic changes of the kidney; however, mild impairment in renal function was observed only at the highest (10 mg Fe /kg bw) concentration of iron sucrose.

Original languageEnglish (US)
Pages (from-to)257-262
Number of pages6
JournalTranslational Research
Volume148
Issue number5
DOIs
StatePublished - Nov 2006
Externally publishedYes

Fingerprint

saccharated ferric oxide
Rats
Kidney
Dialysis
Animals
Iron
Iron Compounds
Fluids
Erythropoietin
Renal Insufficiency
Urea
Gastrointestinal Tract
Wistar Rats
Anemia
Collagen

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, medical
  • Public Health, Environmental and Occupational Health

Cite this

Breborowicz, A., Polubinska, A., Górna, K., Breborowicz, M., & Oreopoulos, D. G. (2006). Iron sucrose induced morphological and functional changes in the rat kidney. Translational Research, 148(5), 257-262. https://doi.org/10.1016/j.trsl.2006.04.008

Iron sucrose induced morphological and functional changes in the rat kidney. / Breborowicz, Andrzej; Polubinska, Alicja; Górna, Kinga; Breborowicz, Maciej; Oreopoulos, Dimitrios G.

In: Translational Research, Vol. 148, No. 5, 11.2006, p. 257-262.

Research output: Contribution to journalArticle

Breborowicz, A, Polubinska, A, Górna, K, Breborowicz, M & Oreopoulos, DG 2006, 'Iron sucrose induced morphological and functional changes in the rat kidney', Translational Research, vol. 148, no. 5, pp. 257-262. https://doi.org/10.1016/j.trsl.2006.04.008
Breborowicz A, Polubinska A, Górna K, Breborowicz M, Oreopoulos DG. Iron sucrose induced morphological and functional changes in the rat kidney. Translational Research. 2006 Nov;148(5):257-262. https://doi.org/10.1016/j.trsl.2006.04.008
Breborowicz, Andrzej ; Polubinska, Alicja ; Górna, Kinga ; Breborowicz, Maciej ; Oreopoulos, Dimitrios G. / Iron sucrose induced morphological and functional changes in the rat kidney. In: Translational Research. 2006 ; Vol. 148, No. 5. pp. 257-262.
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